| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
- PDM2
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- $137.00
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2026-07-27
- CAS:688348-25-6
- Purity: 99.57%
- Supply Ability: 10g
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| | 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Basic information |
| Product Name: | 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE | | Synonyms: | 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE;PDM 2;1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene;PDM-2;PDM2;PDM 2;688348-25-6;Benzene, 1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-;inhibit,Aryl Hydrocarbon Receptor,PDM2,PDM-2,PDM 2,Inhibitor,AhR;(E)-1,3-Dichloro-5-(4-chlorostyryl)benzene | | CAS: | 688348-25-6 | | MF: | C14H9Cl3 | | MW: | 283.58 | | EINECS: | | | Product Categories: | | | Mol File: | 688348-25-6.mol | ![1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Structure](CAS/GIF/688348-25-6.gif) |
| | 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Chemical Properties |
| Boiling point | 394.2±42.0 °C(Predicted) | | density | 1.360±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 2 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Usage And Synthesis |
| Description | The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. PDM 2 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a Ki of 1.2 nM. PDM 2 is inactive as a ligand for the estrogen receptor even at 100 μM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, PDM 2 is a potential therapeutic for the treatment for dioxin and other aryl hydrocarbon poisonings. | | Uses | PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an Ki of 1.2±0.4 nM. | | References | [1] de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. DOI:10.1021/jm0498194 |
| | 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Preparation Products And Raw materials |
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