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| | RORγt Inverse agonist 2 Basic information |
| Product Name: | RORγt Inverse agonist 2 | | Synonyms: | RORγt Inverse agonist 2;Cyclohexanecarboxylic acid, 4-[[(3R)-3-[(4-fluorophenyl)sulfonyl]-3-[4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]-1-pyrrolidinyl]carbonyl]-, trans- | | CAS: | 1801197-92-1 | | MF: | C27H25F8NO5S | | MW: | 627.54 | | EINECS: | | | Product Categories: | | | Mol File: | 1801197-92-1.mol |  |
| | RORγt Inverse agonist 2 Chemical Properties |
| Boiling point | 674.6±55.0 °C(Predicted) | | density | 1.465±0.06 g/cm3(Predicted) | | pka | 4.73±0.10(Predicted) |
| | RORγt Inverse agonist 2 Usage And Synthesis |
| Uses | RORγt Inverse agonist 2 is a selective, orally active RORγt inverse agonist with an EC50 of 119 nM[1]. | | References | [1] Duan JJ, et al. Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists. ACS Med Chem Lett. 2019 Feb 26;10(3):367-373. DOI:10.1021/acsmedchemlett.9b00010 |
| | RORγt Inverse agonist 2 Preparation Products And Raw materials |
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Tag:RORγt Inverse agonist 2(1801197-92-1)
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Cyclohexanecarboxylic acid, 4-[[(3aR,9bR)-9b-[(4-fluorophenyl)sulfonyl]-1,2,3a,4,5,9b-hexahydro-7-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-3H-benz[e]indol-3-yl]carbonyl]-3-methyl-, (3S,4R)-
RORγt Inverse agonist 2
Cyclohexanecarboxylic acid, 4-[[(3aR,9bR)-9b-[(4-fluorophenyl)sulfonyl]-1,2,3a,4,5,9b-hexahydro-7-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-3H-benz[e]indol-3-yl]carbonyl]-3-methyl-, (1R,3S,4R)-
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ROR gamma-t-IN-1
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