N-(Boc-PEG2)-N-bis(PEG3-azide) manufacturers
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| | N-(Boc-PEG2)-N-bis(PEG3-azide) Basic information |
| Product Name: | N-(Boc-PEG2)-N-bis(PEG3-azide) | | Synonyms: | N-(Boc-PEG2)-N-bis(PEG3-azide);N-(t-butyl ester-PEG2)-N-bis(PEG3-azide);(N3-PEG3)2-N-PEG2-COOtBu;tert-Butyl 1-azido-12-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)-13-oxo-3,6,9,16,19-pentaoxa-12-azadocosan-22-oate | | CAS: | 2353409-46-6 | | MF: | C28H53N7O11 | | MW: | 663.77 | | EINECS: | | | Product Categories: | | | Mol File: | 2353409-46-6.mol |  |
| | N-(Boc-PEG2)-N-bis(PEG3-azide) Chemical Properties |
| storage temp. | Storage temp. 2-8°C | | solubility | Soluble in DMSO, DCM, DMF | | form | Viscous Liquid | | color | Colorless to light yellow |
| | N-(Boc-PEG2)-N-bis(PEG3-azide) Usage And Synthesis |
| Description | N-(t-butyl ester-PEG2)-N-bis(PEG3-azide) is a branched conjugation reagent The azide groups is very reactive with alkyne such as DBCO, BCN and propargyl reagnet via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases the hydrophilic properties of the compound. | | Uses | N-(Boc-PEG2)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Boc-PEG2)-N-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-(Boc-PEG2)-N-bis(PEG3-azide) Preparation Products And Raw materials |
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