Azido-PEG4-Val-Cit-PAB-MMAE

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Company Name: Shanghai Send Pharmaceutical Technology Co., Ltd.  
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Azido-PEG4-Val-Cit-PAB-MMAE Basic information
Product Name:Azido-PEG4-Val-Cit-PAB-MMAE
Synonyms:Azido-PEG4-Val-Cit-PAB-MMAE
CAS:1869126-64-6
MF:C69H113N13O17
MW:1396.74
EINECS:
Product Categories:
Mol File:1869126-64-6.mol
Azido-PEG4-Val-Cit-PAB-MMAE Structure
Azido-PEG4-Val-Cit-PAB-MMAE Chemical Properties
storage temp. -20°C, protect from light, stored under nitrogen
solubility Soluble in DMSO, DCM, DMF
form Solid
color White to off-white
Safety Information
MSDS Information
Azido-PEG4-Val-Cit-PAB-MMAE Usage And Synthesis
DescriptionAzido-PEG4-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains an azido-PEG4 spacer, a protease-sensitive Val-Cit dipeptide, a PABC linker and a MMAE payload.Azido enable click chemistry with alkyne-bearing moiety
UsesAzido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH[1]. Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
References[1] Moreadith R, et, al. Polyoxazoline antibody drug conjugates. WO2016019340A1.
Azido-PEG4-Val-Cit-PAB-MMAE Preparation Products And Raw materials
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