Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- manufacturers
- Tovinontrine
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- $142.00
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2026-08-26
- CAS:2062661-53-2
- Purity: 98.80%
- Supply Ability: 10g
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| | Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- Basic information |
| | Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- Chemical Properties |
| density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | form | Solid | | pka | 12.32±0.40(Predicted) | | color | White to off-white |
| | Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- Usage And Synthesis |
| Uses | Tovinontrine (IMR-687) is a highly potent and selective phosphodiesterase-9 (PDE9) inhibitor specifically for the treatment of sickle cell disease. IC50s are 8.19 nM and 9.99 nM for PDE9A1 and PDE9A2, respectively[1]. | | in vivo | IMR-687 (30 mg/kg/day; after 30 days of treatment) shows a greater than 3-fold in the percent of HbF+ F-cells (8.4% in vehicle treated and 27.3% in IMR-687 treated) and a corresponding 2-fold decrease in sickled red blood cells (56.3% in vehicle treated and 24.4% in IMR-687 treated)[1]. | Animal Model: | HbSS-Townes mice on a 129/B6 background (10-12 weeks old) [1] | | Dosage: | 30 mg/kg | | Administration: | Dosed daily by gavage for 30 days | | Result: | Resulted in fetal hemoglobin (HbF) induction, reduced hemolysis and reduced reticulocytosis. |
| | IC 50 | PDE9A1: 8.19 nM (); PDE9A2: 9.99 nM (); PDE1A3: 88.4 nM (); PDE1B: 8.48 nM (); PDE1C: 12.2 nM (); PDE5A2: 81.9 nM () | | References | [1] James G McArthur, et al. A novel, highly potent and selective phosphodiesterase-9 inhibitor for the treatment of sickle cell disease. Haematologica. 2020 Mar;105(3):623-631. DOI:10.3324/haematol.2018.213462 |
| | Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- Preparation Products And Raw materials |
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