Benzamide, N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo-

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Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:CU-115
CAS:2471982-20-2
Purity:100% Package:1mg;53USD|5mg;147USD|10mg;239USD
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Products Intro: Product Name:CU-115
CAS:2471982-20-2
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Products Intro: Product Name:CU-115
CAS:2471982-20-2
Purity:99% Package:$140.9/1mg;$480.9/5mg;Bulk package Remarks:99%
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Products Intro: Product Name:CU-115
CAS:2471982-20-2
Purity:99% Package:1mg;2mg;5mg
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Products Intro: Product Name:CU-115
CAS:2471982-20-2
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Benzamide, N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo- manufacturers

  • CU-115
  • CU-115 pictures
  • $32.00
  • 2026-07-27
  • CAS:2471982-20-2
  • Purity: 99.96%
  • Supply Ability: 10g
Benzamide, N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo- Basic information
Product Name:Benzamide, N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo-
Synonyms:Benzamide, N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo-;CU-115, 10 mM in DMSO
CAS:2471982-20-2
MF:C21H11F7INO2
MW:569.21
EINECS:
Product Categories:
Mol File:2471982-20-2.mol
Benzamide, N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo- Structure
Benzamide, N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo- Chemical Properties
Boiling point 427.3±45.0 °C(Predicted)
density 1.713±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 10mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:5): 0.15mg/mL,Ethanol: 0.25mg/mL
form A crystalline solid
pka11.28±0.70(Predicted)
color White to off-white
Safety Information
MSDS Information
Benzamide, N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo- Usage And Synthesis
UsesCU-115 is a potent TLR8 antagonist (IC50=1.04 μM), and shows selective for TLR8 over TLR7 (IC50=>50 μM). CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells[1].
IC 50TLR8: 1.04 μM (IC50); TLR7: 50 μM (IC50)
References[1] Rosaura Padilla-Salinas, et al. Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors 7 and 8. J Med Chem. 2019 Nov 27;62(22):10221-10244. DOI:10.1021/acs.jmedchem.9b01201
Benzamide, N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo- Preparation Products And Raw materials
Tag:Benzamide, N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo-(2471982-20-2) Related Product Information
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