6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine

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6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine Basic information
Product Name:6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine
Synonyms:PD 160170;8-Quinolinamine, 6-[[2-(1-methylethyl)phenyl]sulfonyl]-5-nitro-;6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine
CAS:181468-88-2
MF:C18H17N3O4S
MW:371.41
EINECS:
Product Categories:Neuropeptide Y (NPY ) receptor
Mol File:181468-88-2.mol
6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine Structure
6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine Chemical Properties
Boiling point 646.6±55.0 °C(Predicted)
density 1.379±0.06 g/cm3(Predicted)
storage temp. Store at RT
solubility Soluble to 100 mM in DMSO
form Powder
pka-1.16±0.12(Predicted)
Safety Information
MSDS Information
6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine Usage And Synthesis
UsesPD 160170 is a compound developed to inhibit low-risk myelodysplastic syndrome-associated anemia with activities that promote red blood cell transfusion independence and increase hemoglobin.
DefinitionChEBI: 5-nitro-6-(2-propan-2-ylphenyl)sulfonyl-8-quinolinamine is a nitro compound and a member of quinolines.
Biological ActivityPotent, selective non-peptidic neuropeptide Y 1 receptor antagonist (K i = 48 nM); selective over Y 2 and Y 5 receptors (K i > 10 μ M). Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells (IC 50 = 8.2 nM).
References[1] 8-Amino-5-nitro-6-phenoxyquinolines: potential non-peptidic neuropeptide Y receptor ligands
6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine Preparation Products And Raw materials
Tag:6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine(181468-88-2) Related Product Information
2-(Phenylsulfonyl)aniline 2-Nitrophenyl phenyl sulfone 6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine [Leu31,Pro34]-Neuropeptide Y(human,rat,mouse) TFA Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-NH2 Spexin