[6-甲氧基-2-(4-甲氧基苯基)苯并[B]呋喃-3-基](4-氰基苯基)甲酮
| 中文名称 | [6-甲氧基-2-(4-甲氧基苯基)苯并[B]呋喃-3-基](4-氰基苯基)甲酮 |
|---|---|
| 中文同义词 | [6-甲氧基-2-(4-甲氧基苯基)苯并[B]呋喃-3-基](4-氰基苯基)甲酮;化合物 T22951;化合物 LY320135 |
| 英文名称 | 4-[[6-METHOXY-2-(4-METHOXYPHENYL)-3-BENZOFURANYL]CARBONYL]BENZONITRILE |
| 英文同义词 | 4-[6-Methoxy-2-(4-Methoxyphenyl)benzofuran-3-carbonyl]benzonitrile;[6-Methoxy-2-(4-methoxyphenyl)benzo[b]furan-3-yl](4-cyanophenyl)methanone;4-[[6-METHOXY-2-(4-METHOXYPHENYL)-3-BENZOFURANYL]CARBONYL]BENZONITRILE;LY320135;Benzonitrile,4-[[6-Methoxy-2-(4-Methoxyphenyl)-3-benzofuranyl]carbonyl]-;LY320135,LY-320135 |
| CAS号 | 176977-56-3 |
| 分子式 | C24H17NO4 |
| 分子量 | 383.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 176977-56-3.mol |
| 结构式 | ![[6-甲氧基-2-(4-甲氧基苯基)苯并[B]呋喃-3-基](4-氰基苯基)甲酮 结构式](CAS/GIF/176977-56-3.gif) |
[6-甲氧基-2-(4-甲氧基苯基)苯并[B]呋喃-3-基](4-氰基苯基)甲酮 性质
| 沸点 | 617.2±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.31±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥10mg/mL |
| 形态 | 粉末 |
| 颜色 | 橙色 |
| InChI | 1S/C24H17NO4/c1-27-18-9-7-17(8-10-18)24-22(20-12-11-19(28-2)13-21(20)29-24)23(26)16-5-3-15(14-25)4-6-16/h3-13H,1-2H3 |
| InChIKey | RYNSGDFWBJWWSZ-UHFFFAOYSA-N |
| SMILES | COc1ccc(cc1)-c2oc3cc(OC)ccc3c2C(=O)c4ccc(cc4)C#N |
|
CB1 141 nM (Ki) |
5-HT 2 Receptor 6.4 μM (Ki) |
muscarinic receptor 2.1 μM (Ki) |
CB2 >10 μM (Ki) |
LY320135 has a relatively low affinity for the CB2 receptor (K
i
=14.9±0.4 μM) and ten other unrelated receptors.
LY320135 (1 nM-10 μM) inhibits the anandamide-mediated forskolin-stimulated cAMP accumulation in CHO cell, with an IC
50
of 734±122 nM.
LY320135 (0.1-1000 nM; 1-8 min) can reverse calcium current (I
Ca
) inhibition by WIN 55212-2 in N18 cells, with an IC
50
of 55±10 nM.
LY320135 (1 μM) prevents activation of K
ir
current by WIN 55212-2 in AtT-20-CB1 cells.
LY 320135 (0.001-1 μM) reduces CA1 injury induced by 20 min oxygen-glucose deprivation (OGD) in a concentration-dependent manner.