4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile

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4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile manufacturers

  • LY320135
  • LY320135 pictures
  • $673.00
  • 2026-05-11
  • CAS:176977-56-3
  • Purity:
  • Supply Ability: 10g
4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile Basic information
Product Name:4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile
Synonyms:4-[6-Methoxy-2-(4-Methoxyphenyl)benzofuran-3-carbonyl]benzonitrile;[6-Methoxy-2-(4-methoxyphenyl)benzo[b]furan-3-yl](4-cyanophenyl)methanone;LY320135;Benzonitrile,4-[[6-Methoxy-2-(4-Methoxyphenyl)-3-benzofuranyl]carbonyl]-;LY320135,LY-320135;4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile
CAS:176977-56-3
MF:C24H17NO4
MW:383.4
EINECS:
Product Categories:
Mol File:176977-56-3.mol
4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile Structure
4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile Chemical Properties
Boiling point 617.2±55.0 °C(Predicted)
density 1.31±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥10mg/mL
form powder
color orange
InChI1S/C24H17NO4/c1-27-18-9-7-17(8-10-18)24-22(20-12-11-19(28-2)13-21(20)29-24)23(26)16-5-3-15(14-25)4-6-16/h3-13H,1-2H3
InChIKeyRYNSGDFWBJWWSZ-UHFFFAOYSA-N
SMILESCOc1ccc(cc1)-c2oc3cc(OC)ccc3c2C(=O)c4ccc(cc4)C#N
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany 3
Storage Class6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard ClassificationsAcute Tox. 3 Oral
MSDS Information
4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile Usage And Synthesis
Uses[6-Methoxy-2-(4-methoxyphenyl)benzo[b]furan-3-yl](4-cyanophenyl)methanone is a selective antagonist for the brain CB1 receptor, having greater than 70-fold higher affinity for the CB1 than the periphe ral CB2 receptor. [6-Methoxy-2-(4-methoxyphenyl)benzo[b]furan-3-yl](4-cyanophenyl)methanone is a promising lead compound for the further development of selective cannabinoid antagonists of novel struc ture.
DefinitionChEBI: 4-[[6-methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]-oxomethyl]benzonitrile is a member of benzofurans.
Biochem/physiol ActionsLY320135 is a potent CB1 receptor antagonist/inverse agonist (Ki = 141 nM) with greater than 70-fold selectivity over CB2 receptors (Ki > 10 μM). Structurally dissimilar from SR 141716A and AM 251. Shows weak binding to both 5-HT2 (Ki = 6.4 μM) and muscarinic receptors (Ki = 2.1 μM)
IC 50CB1: 141 nM (Ki); 5-HT2 Receptor: 6.4 μM (Ki); muscarinic receptor: 2.1 μM (Ki); CB2: >10 μM (Ki)
storageStore at RT
4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile Preparation Products And Raw materials
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