| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:[6-Methoxy-2-(4-Methoxyphenyl)benzo[b]furan-3-yl](4-cyanophenyl)Methanone
CAS:176977-56-3
Package:100Mg,10Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:LY 320135;4-[[6-Methoxy-2-(4-Methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile
CAS:176977-56-3
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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4-[[6-METHOXY-2-(4-METHOXYPHENYL)-3-BENZOFURANYL]CARBONYL]BENZONITRILE manufacturers
- LY320135
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- $673.00 / 10mg
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2026-01-04
- CAS:176977-56-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 4-[[6-METHOXY-2-(4-METHOXYPHENYL)-3-BENZOFURANYL]CARBONYL]BENZONITRILE Basic information |
| Product Name: | 4-[[6-METHOXY-2-(4-METHOXYPHENYL)-3-BENZOFURANYL]CARBONYL]BENZONITRILE | | Synonyms: | 4-[6-Methoxy-2-(4-Methoxyphenyl)benzofuran-3-carbonyl]benzonitrile;[6-Methoxy-2-(4-methoxyphenyl)benzo[b]furan-3-yl](4-cyanophenyl)methanone;4-[[6-METHOXY-2-(4-METHOXYPHENYL)-3-BENZOFURANYL]CARBONYL]BENZONITRILE;LY320135;Benzonitrile,4-[[6-Methoxy-2-(4-Methoxyphenyl)-3-benzofuranyl]carbonyl]-;LY320135,LY-320135 | | CAS: | 176977-56-3 | | MF: | C24H17NO4 | | MW: | 383.4 | | EINECS: | | | Product Categories: | | | Mol File: | 176977-56-3.mol | ![4-[[6-METHOXY-2-(4-METHOXYPHENYL)-3-BENZOFURANYL]CARBONYL]BENZONITRILE Structure](CAS/GIF/176977-56-3.gif) |
| | 4-[[6-METHOXY-2-(4-METHOXYPHENYL)-3-BENZOFURANYL]CARBONYL]BENZONITRILE Chemical Properties |
| Boiling point | 617.2±55.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ≥10mg/mL | | form | powder | | color | orange | | InChI | 1S/C24H17NO4/c1-27-18-9-7-17(8-10-18)24-22(20-12-11-19(28-2)13-21(20)29-24)23(26)16-5-3-15(14-25)4-6-16/h3-13H,1-2H3 | | InChIKey | RYNSGDFWBJWWSZ-UHFFFAOYSA-N | | SMILES | COc1ccc(cc1)-c2oc3cc(OC)ccc3c2C(=O)c4ccc(cc4)C#N |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral |
| | 4-[[6-METHOXY-2-(4-METHOXYPHENYL)-3-BENZOFURANYL]CARBONYL]BENZONITRILE Usage And Synthesis |
| Uses | [6-Methoxy-2-(4-methoxyphenyl)benzo[b]furan-3-yl](4-cyanophenyl)methanone is a selective antagonist for the brain CB1 receptor, having greater than 70-fold higher affinity for the CB1 than the periphe
ral CB2 receptor. [6-Methoxy-2-(4-methoxyphenyl)benzo[b]furan-3-yl](4-cyanophenyl)methanone is a promising lead compound for the further development of selective cannabinoid antagonists of novel struc
ture. | | Definition | ChEBI: 4-[[6-methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]-oxomethyl]benzonitrile is a member of benzofurans. | | Biochem/physiol Actions | LY320135 is a potent CB1 receptor antagonist/inverse agonist (Ki = 141 nM) with greater than 70-fold selectivity over CB2 receptors (Ki > 10 μM). Structurally dissimilar from SR 141716A and AM 251. Shows weak binding to both 5-HT2 (Ki = 6.4 μM) and muscarinic receptors (Ki = 2.1 μM) | | IC 50 | CB1: 141 nM (Ki); 5-HT2 Receptor: 6.4 μM (Ki); muscarinic receptor: 2.1 μM (Ki); CB2: >10 μM (Ki) | | storage | Store at RT |
| | 4-[[6-METHOXY-2-(4-METHOXYPHENYL)-3-BENZOFURANYL]CARBONYL]BENZONITRILE Preparation Products And Raw materials |
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