| Company Name: |
ChemeGen |
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18818260767 |
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| | (±)11-HETE-d8 Basic information |
| Product Name: | (±)11-HETE-d8 | | Synonyms: | (±)11-HETE-d8;(±)11-HETE-d8 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![(±)11-HETE-d8 Structure]() |
| | (±)11-HETE-d8 Chemical Properties |
| solubility | DMF: 20 mg/ml
DMSO: 20 mg/ml
Ethanol: 50 mg/mlPBS (pH 7.2): 0.5 mg/ml |
| | (±)11-HETE-d8 Usage And Synthesis |
| Description | (±)11-HETE-d8 is intended for use as an internal standard for the quantification of 11-HETE by GC- or LC-MS. (±)11-HETE is formed non-enzymatically from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).1,2 11(R)-HETE is formed from arachidonic acid by COX-1, COX-2, and aspirin-acetylated COX-2.3,4 11(R)- and 11(S)-HETE are formed from arachidonic acid via cytochrome P450 (CYP), with 11(R)-HETE formed at a higher ratio than 11(S)-HETE.5WARNING This product is not for human or veterinary use. | | References | [1] WILLIAM S. POWELL Joshua R. Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2015, 1851 4: Pages 340-355. DOI: 10.1016/j.bbalip.2014.10.008
[2] PRISCILLA BENTO MATOS CRUZ DEROGIS Sayuri M Adriano B Chaves Fillho. Characterization of Hydroxy and Hydroperoxy Polyunsaturated Fatty Acids by Mass Spectrometry.[J]. Advances in experimental medicine and biology, 2019, 1127: 21-35. DOI: 10.1007/978-3-030-11488-6_2
[3] E D THURESSON W L S K M Lakkides. Different catalytically competent arrangements of arachidonic acid within the cyclooxygenase active site of prostaglandin endoperoxide H synthase-1 lead to the formation of different oxygenated products.[J]. The Journal of Biological Chemistry, 2000, 275 12: 8501-8507. DOI: 10.1074/jbc.275.12.8501
[4] GUISHAN XIAO. Analysis of Hydroperoxide-Induced Tyrosyl Radicals and Lipoxygenase Activity in Aspirin-Treated Human Prostaglandin H Synthase-2†[J]. Biochemistry Biochemistry, 1997, 36 7: 1836-1845. DOI: 10.1021/bi962476u
[5] JORGE CAPDEVILA . Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450[J]. Biochemical and biophysical research communications, 1986, 141 3: Pages 1007-1011. DOI: 10.1016/s0006-291x(86)80144-9 |
| | (±)11-HETE-d8 Preparation Products And Raw materials |
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