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| | 12-HETE-d8 Basic information |
| Product Name: | 12-HETE-d8 | | Synonyms: | (+/-)12-HETE-d8;(5Z,8Z,10E,14Z)-5,6,8,9,11,12,14,15-octadeuterio-12-hydroxyicosa-5,8,10,14-tetraenoic acid | | CAS: | 2525175-25-9 | | MF: | C20H24D8O3 | | MW: | 328.52 | | EINECS: | | | Product Categories: | | | Mol File: | 2525175-25-9.mol |  |
| | 12-HETE-d8 Chemical Properties |
| Boiling point | 487.676±45.00 °C(Press: 760.00 Torr)(predicted) | | density | 0.984±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | 0.1 M Na2CO3: 2 mg/ml
DMF: miscible
DMSO: miscible
Ethanol: misciblePBS (pH 7.4): 0.8 mg/ml | | form | Liquid | | color | Colorless to light yellow |
| | 12-HETE-d8 Usage And Synthesis |
| Uses | 12-HETE-d8 is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway[1].12-HETE has both anti-thrombotic and pro-thrombotic effects[2]. 12-HETE is a neuromodulator[3]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Qian Liu, et al. 12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer. Cancer Manag Res. 2018 Nov 16;10:5825-5838. DOI:10.2147/CMAR.S180334
[3] Benedetta Porro, et al. Analysis, physiological and clinical significance of 12-HETE: a neglected platelet-derived 12-lipoxygenase product. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:26-40. DOI:10.1016/j.jchromb.2014.03.015
[4] Aidan J Hampson, et al. 12-hydroxyeicosatetrenoate (12-HETE) attenuates AMPA receptor-mediated neurotoxicity: evidence for a G-protein-coupled HETE receptor. J Neurosci. 2002 Jan 1;22(1):257-64. DOI:10.1523/JNEUROSCI.22-01-00257.2002
[5] WILLIAM S. POWELL Joshua R. Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2015, 1851 4: Pages 340-355. DOI: 10.1016/j.bbalip.2014.10.008
[6] PRISCILLA BENTO MATOS CRUZ DEROGIS Sayuri M Adriano B Chaves Fillho. Characterization of Hydroxy and Hydroperoxy Polyunsaturated Fatty Acids by Mass Spectrometry.[J]. Advances in experimental medicine and biology, 2019, 1127: 21-35. DOI: 10.1007/978-3-030-11488-6_2
[7] HARTMUT KUHN Klaus van L Swathi Banthiya. Mammalian lipoxygenases and their biological relevance[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2015, 1851 4: Pages 308-330. DOI: 10.1016/j.bbalip.2014.10.002
[8] F BÜRGER. Positional- and stereo-selectivity of fatty acid oxygenation catalysed by mouse (12S)-lipoxygenase isoenzymes.[J]. Biochemical Journal, 2000, 348 Pt 2: 329-335.
[9] DAVID MERIWETHER. Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model.[J]. Journal of Clinical Investigation, 2019, 129 9: 3670-3685. DOI: 10.1172/jci123700 |
| | 12-HETE-d8 Preparation Products And Raw materials |
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