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| | 2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]- Basic information |
| | 2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]- Chemical Properties |
| Boiling point | 1003.2±65.0 °C(Predicted) | | density | 0.963±0.06 g/cm3(Predicted) | | solubility | Chloroform: soluble; Ethanol: soluble; Methanol: soluble | | form | Liquid | | pka | 12.87±0.60(Predicted) | | color | Colorless to light yellow | | InChIKey | ZISVTYVLWSZJAL-UHFFFAOYSA-N | | SMILES | N1C(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C(=O)NC(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C1=O |
| | 2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]- Usage And Synthesis |
| Description | CKK-E12 is an ionizable lipid. It is useful for Development of Lipidoid Nanoparticles for siRNA, mRNA, and vaccine delivery. | | Uses | CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo, | | in vivo | CKK-E12 delivers siRNA in mice, rats and primates (ED50 is 0.002, 0.01 and 0.3 mg/kg, respectively)[1].
| | References | [1] Dong Y, Love KT, Dorkin JR, et al. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates [published correction appears in Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5753].Proc Natl Acad Sci U S A. 2014;111(11):3955-3960. DOI:10.1073/pnas.1322937111
[2] Oberli MA, Reichmuth AM, Dorkin JR, et al. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett. 2017;17(3):1326-1335. DOI:10.1021/acs.nanolett.6b03329
[3] Hatit MZC, et al. Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles. Nat Nanotechnol. 2022 Mar;17(3):310-318. doi: 10.1038/s41565-021-01030-y. Epub 2022 Feb 7. DOI:10.1038/s41565-021-01030-y |
| | 2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]- Preparation Products And Raw materials |
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