| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:QuinupraMine
CAS:31721-17-2
Package:250Mg,25Mg
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:QuinupraMine;5-(1-Azabicyclo[2.2.2]oct-3-yl)-10,11-dihydro-5H-dibenz[b,f]azepine; 10,11-Dihydro-5-(3-quinuclidinyl)-5H-dibenz[b,f]azepine; Kevopril; Kinupril; LM 208
CAS:31721-17-2
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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| | quinupramine Basic information |
| Product Name: | quinupramine | | Synonyms: | quinupramine;10,11-Dihydro-5-(quinuclidin-3-yl)-5H-dibenz[b,f]azepine;10,11-Dihydro-5-(3-quinuclidinyl)-5H-dibenz(B,F)azepine;5-(3-Chinuclidinyl)-10,11-dihydro-5H-dibenz(B,F)azepin;5H-Dibenz(B,F)azepine, 10,11-dihydro-5-(3-quinuclidinyl)-;Einecs 250-780-3;Quinupramina;Quinupramina [inn-spanish] | | CAS: | 31721-17-2 | | MF: | C21H24N2 | | MW: | 304.43 | | EINECS: | 250-780-3 | | Product Categories: | | | Mol File: | 31721-17-2.mol |  |
| | quinupramine Chemical Properties |
| Melting point | 150° | | Boiling point | 445.2±44.0 °C(Predicted) | | density | 1.19±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator, under inert atmosphere | | solubility | Chloroform (Slightly), DMSO (Slightly, Sonicated) | | pka | 10.00±0.33(Predicted) | | form | Solid | | color | Brown |
| RIDADR | 3249 | | HazardClass | 6.1(b) | | PackingGroup | III |
| | quinupramine Usage And Synthesis |
| Uses | Quinupramine is an analog of Imipramine (I465980). Quinupramine is used as an antidepressant. | | Definition | ChEBI: Quinupramine is a dibenzooxazepine. | | in vivo | Quinupramine (10 mg/kg, PO, twice daily for 10 days) causes a down-regulation of serotonin S2 receptors in the frontal cortex of the rat[2].
Quinupramine-EVA matrix containing a permeation enhancer can be a good transdermal delivery system for providing sustained plasma concentrations[3]. | Animal Model: | Sprague-Dawley rats (Male, 220-270 g) | | Dosage: | 10 mg/kg | | Administration: | PO, twice daily for 10 days | | Result: | Caused a down-requlation of serotonin S2 receptors in the frontal cortex of the rat, did not alter the binding populations of Q-adrenergic, muscarinic cholinergic and a2-adrenergic receptors in the rat brain. |
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| | quinupramine Preparation Products And Raw materials |
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