3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone

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3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone manufacturers

  • EMI1
  • EMI1 pictures
  • $35.00
  • 2026-08-21
  • CAS:35773-42-3
  • Purity: 99.96%
  • Supply Ability: 10g
3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone Basic information
Product Name:3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone
Synonyms:2H-1-Benzopyran-2-one, 3-(2-benzoxazolyl)-7-(diethylamino)-;3-(Benzoxazol-2-yl)-7-diethylamino-2H-1-benzopyran-2-one;3-(Benzoxazole-2-yl)-7-(diethylamino)-2H-1-benzopyran-2-one;7-(Diethylamino)-3-(benzoxazole-2-yl)-2H-1-benzopyran-2-one;3-(1,3-benzoxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one;3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone;EMI1 (EGFR MaMTH Inhibitor 1);ChemBridge-5213777
CAS:35773-42-3
MF:C20H18N2O3
MW:334.37
EINECS:252-721-7
Product Categories:
Mol File:35773-42-3.mol
3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone Structure
3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone Chemical Properties
Melting point 185-186 °C(Solv: N,N-dimethylformamide (68-12-2))
Boiling point 551.0±60.0 °C(Predicted)
density 1.284±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 2mg/mL, clear
form Solid
pka2.94±0.20(Predicted)
color Light yellow to yellow
InChI1S/C20H18N2O3/c1-3-22(4-2)14-10-9-13-11-15(20(23)25-18(13)12-14)19-21-16-7-5-6-8-17(16)24-19/h5-12H,3-4H2,1-2H3
InChIKeyUJOQSHCJYVRZKJ-UHFFFAOYSA-N
SMILESN(CC)(CC)c1cc2[o][c](c(cc2cc1)c3nc4c([o]3)cccc4)=O
EPA Substance Registry System2H-1-Benzopyran-2-one, 3-(2-benzoxazolyl)-7-(diethylamino)- (35773-42-3)
Safety Information
WGK Germany WGK 3
TSCA TSCA listed
Storage Class11 - Combustible Solids
MSDS Information
3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone Usage And Synthesis
UsesEMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor. EMI1 can be used for the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)[1].
Biological ActivityEMI1 (ChemBridge 5213777) is a call penetrant and potent inhibitor of EGFR signaling in EGFR L858R/T790M/C797S and ex19del/T790M/C797S triple mutants associated with drug-resistant NSCLC. Additionally, EMI1 potently depolymerized interphase microtubules, disrupts spindle formation and induced mitotic block in PC9 EGFR ex19del/T790M/C797S cells. EMI1 exhibits potent anti-proliferative activity against various cancer cell lines.
IC 50EGFRdel19 T790M C797S; EGFRL858R/T790M/C797S
References[1] Punit Saraon, et al. A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat Chem Biol. 2020 May;16(5):577-586. DOI:10.1038/s41589-020-0484-2
3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone Preparation Products And Raw materials
Tag:3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone(35773-42-3) Related Product Information
Disperse Yellow 232 (E)-2-Styrylbenzoxazole 7-(diethylamino)-3-(5-methylbenzoxazol-2-yl)-2-benzopyrone 2-ETHYL-BENZOOXAZOLE BENZOOXAZOL-2-YL-ACETIC ACID 3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone