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Wuhan chuang he chemical co. LTD
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15907120073 |
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1261789306@qq.com |
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Product Name:208109-39-1
CAS:208109-39-1
Purity:98 Package:1g
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| Company Name: |
Bide Pharmatech Ltd.
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400-1647117 13681763483 |
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Product Name:(3-Chloro-4-fluorophenyl)(4-fluoro-4-((((5-methyl-6-(methylamino)pyridin-2-yl)methyl)amino)methyl)piperidin-1-yl)methanone fumarate
CAS:208109-39-1
Purity:98% Package:10mg;25mg;50mg;100mg Remarks:BD01426510
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| Company Name: |
InvivoChem
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13549236410 |
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sales@invivochem.cn |
| Products Intro: |
Product Name:F13714 fumarate
CAS:208109-39-1
Purity:98% HPLC Package:1mg Remarks:V3527
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F13714 fumarate manufacturers
- F13714 fumarate
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- $52.00 / 1mg
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2024-11-19
- CAS:208109-39-1
- Min. Order:
- Purity: 98.86%
- Supply Ability: 10g
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| | F13714 fumarate Basic information |
| Product Name: | F13714 fumarate | | Synonyms: | F13714 fumarate;(3-Chloro-4-fluorophenyl)(4-fluoro-4-((((5-methyl-6-(methylamino)pyridin-2-yl)methyl)amino)methyl)piperidin-1-yl)methanone fumarate;4-Piperidinemethanamine, 1-(3-chloro-4-fluorobenzoyl)-4-fluoro-N-[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]-, (2E)-2-butenedioate (1:1) | | CAS: | 208109-39-1 | | MF: | | | MW: | 538.97 | | EINECS: | | | Product Categories: | | | Mol File: | 208109-39-1.mol |  |
| | F13714 fumarate Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 250 mg/mL (463.85 mM; Need ultrasonic) | | form | Solid | | color | Yellow to brown |
| | F13714 fumarate Usage And Synthesis |
| Uses | F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress[1]. | | Biological Activity | F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress[1].
F13714 targets 5-HT1A autoreceptors[1].
In UCMS mice, a single administration of F13714 (4-16 mg/kg) is sufficient to robustly normalize depressive-like behavior in the forced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels[1]. F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5%[1].F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement[1]. F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in na?ve rats[1]. | | in vivo | In UCMS mice, a single administration of F13714 (4–16 mg/kg) is sufficient to robustly normalize depressive-like behavior in the forced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels[1].
F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5%[1].
F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement[1].
F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in na?ve rats[1]. | | IC 50 | 5-HT1A Receptor | | References | [1]. Monika G?uch-Lutwin, et al. The selective 5-HT 1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress. Psychopharmacology (Berl). 2021 May 10. |
| | F13714 fumarate Preparation Products And Raw materials |
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