F13714 fumarate NEW
| Price | $52 | $123 | $198 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: F13714 fumarate | CAS No.: 208109-39-1 |
| Purity: 98.86% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | F13714 fumarate |
| Description | F13714 fumarate is a selective 5-HT1A receptor-biased agonist with antidepressant-like properties after a single dose in a mouse model of chronic mild stress. |
| In vitro | F13714 targets the 5-HT1A autoreceptor[1]. |
| In vivo | METHODS: F13714 fumarate (1, 2, 4, 8, 16 mg/kg, oral) was administered to mice, and the antidepressant-like properties of the compound and its effects on cognitive function were evaluated using the forced swim test (FST) and novel object recognition (NOR), respectively; the depressive-like state was induced by the unpredictable chronic mild stress (UCMS) procedure to test the activity of F13714 fumarate in the depression model, and then sucrose preference, FST and locomotor activity were measured. The levels of phosphorylated cyclic AMP response element binding protein (p-CREB) and phosphorylated extracellular signal-regulated kinase (p-ERK1/2) were also determined. RESULTS: F13714 fumarate (2 and 4 mg/kg, p.o.) reduced immobility time in the FST, suggesting antidepressant-like properties in mice; F15599 did not disrupt long-term memory consolidation in the NOR at any dose tested, whereas F13714 fumarate impaired memory formation, especially at higher doses (4-16 mg/kg); F13714 fumarate rescued cortical and hippocampal deficits in p-ERK1/2 levels in UCMS mice, but did not affect p-CREB levels. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 200 mg/mL (371.08 mM), Sonication is recommended. |
| Keywords | F 13714 Fumarate |
| Inhibitors Related | Alverine citrate | Olanzapine | Dapoxetine hydrochloride | CLOZAPINE N-OXIDE | Amitriptyline hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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