4,4,4-Trifluoro-3-oxo-butyric acid

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4,4,4-Trifluoro-3-oxo-butyric acid manufacturers
4,4,4-Trifluoro-3-oxo-butyric acid Basic information
Product Name:4,4,4-Trifluoro-3-oxo-butyric acid
Synonyms:4,4,4-trifluoro-3-oxobutanoic acid;Butanoic acid, 4,4,4-trifluoro-3-oxo-;4,4,4-Trifluoro-3-oxo-butyric acid
CAS:400-36-2
MF:C4H3F3O3
MW:156.06
EINECS:
Product Categories:
Mol File:400-36-2.mol
4,4,4-Trifluoro-3-oxo-butyric acid Structure
4,4,4-Trifluoro-3-oxo-butyric acid Chemical Properties
Boiling point 189.6±40.0 °C(Predicted)
density 1.519
storage temp. 2-8°C
pka0.83±0.32(Predicted)
Safety Information
MSDS Information
4,4,4-Trifluoro-3-oxo-butyric acid Usage And Synthesis
Synthesis
Butanoyl chloride, 4,4,4-trifluoro-3-oxo-

2261-53-2

4,4,4-TRIFLUORO-3-OXO-BUTYRIC ACID

400-36-2

Example 5: Reaction (ReacSO-1) To a 1,2-dichloroethane solution (758 g) of crude 4,4,4-trifluoro-3-oxobutanoyl chloride (ca. 1.29 mol) was added slowly and dropwise over a period of 2 hr. to a dioxane solution (214 g) containing 1.29 mol of water (23.3 g), at -40°C to -20°C. Upon completion of the reaction, the concentration of the enolized form of compound (II-II) in the resulting solution (981 g) was determined to be 19 wt% by 1H NMR analysis (with cyclobutanesulfone as the internal standard), which corresponded to a yield of 92%.

References[1] Patent: WO2015/4035, 2015, A1. Location in patent: Page/Page column 15
4,4,4-Trifluoro-3-oxo-butyric acid Preparation Products And Raw materials
Raw materialsButanoyl chloride, 4,4,4-trifluoro-3-oxo--->Ethyl 4,4,4-trifluoroacetoacetate-->1,4-Dioxane-->1,2-Dichloroethane
Preparation Products6-methoxy-4-(trifluoromethyl)-1H-quinolin-2-one
Tag:4,4,4-Trifluoro-3-oxo-butyric acid(400-36-2) Related Product Information
METHYL 4,4,4-TRIFLUOROACETOACETATE ETHYL 2-METHYL-4,4,4-TRIFLUOROACETOACETATE Ethyl 2-chloro-4,4,4-trifluoroacetoacetate ISOPROPYL 4,4,4-TRIFLUOROACETOACETATE Ethyl 4,4,4-trifluoroacetoacetate Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate 4,4,4-Trifluoro-acetoacetic acid tert-butyl ester ETHYL 4,4,4-TRIFLUORO-2-METHOXY-3-OXOBUTYRATE ETHYL 4,4,4-TRIFLUORO-2-(TRIPHENYLPHOSPHORANYLIDENE)ACETOACETATE 4,4,4-Trifluoro-2-hydroxylimino-3-oxobutyric acid ethyl ester α-Trifluoroacetyl-G-butyrolactone 4,4,4-TRIFLUORO-3-OXO-2-(PHENYLHYDRAZONO)BUTYRIC ACID ETHYL ESTER ETHYL 3-([2-ACETYL-5-(TERT-BUTYL)-3-THIENYL]AMINO)-2-(2,2,2-TRIFLUOROACETYL)ACRYLATE METHYL 4-([2-(ETHOXYCARBONYL)-4,4,4-TRIFLUORO-3-OXOBUT-1-ENYL]AMINO)THIOPHENE-3-CARBOXYLATE METHYL 2-([2-(ETHOXYCARBONYL)-4,4,4-TRIFLUORO-3-OXOBUT-1-ENYL]AMINO)BENZOATE METHYL 2-([2-(ETHOXYCARBONYL)-4,4,4-TRIFLUORO-3-OXOBUT-1-ENYL]AMINO)THIOPHENE-3-CARBOXYLATE ETHYL 2-(2,6-DICHLOROBENZYL)-4,4,4-TRIFLUOROACETOACETATE ETHYL TRIFLUOROACETYLBROMOACETATE