2-Amino-5-Acetylpyridine manufacturers
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| | 2-Amino-5-Acetylpyridine Basic information |
| Product Name: | 2-Amino-5-Acetylpyridine | | Synonyms: | Ethanone, 1-(6-amino-3-pyridinyl)-;1-(6-Amino-3-pyridinyl)-1-ethanone;3-Acetyl-6-aminopyridine;1-(6-Amino-3-pyridinyl)-ethanone;2-Amino-5-Acetylpyridine;5-ACETO-2-AMINOPYRIDINE;5-Acetyl-2-aminopyridine;2-acetyl 5- amino pyridine | | CAS: | 19828-20-7 | | MF: | C7H8N2O | | MW: | 136.15 | | EINECS: | | | Product Categories: | | | Mol File: | 19828-20-7.mol |  |
| | 2-Amino-5-Acetylpyridine Chemical Properties |
| Boiling point | 332℃ | | density | 1.168 | | Fp | 155℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 4.76±0.13(Predicted) | | Appearance | Light yellow to yellow Solid |
| | 2-Amino-5-Acetylpyridine Usage And Synthesis |
| Synthesis | Step 4 Synthesis of 1-(6-aminopyridin-3-yl)ethanone: To a 1L autoclave was added a saturated aqueous ammonia solution (750 mL) of 1-(6-chloropyridin-3-yl)ethanone (40 g, 257.10 mmol). The reaction mixture was stirred at 130°C for 10 hours. After completion of the reaction, the mixture was cooled and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent ratio 50:1 dichloromethane/methanol) to afford the target compound 1-(6-aminopyridin-3-yl)ethanone in a yield of 33 g in 89% yield as a yellow solid. | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 23, p. 6093 - 6096
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 24, p. 6482 - 6485
[3] Patent: US2007/27184, 2007, A1. Location in patent: Page/Page column 17; 19
[4] Patent: WO2017/184547, 2017, A1. Location in patent: Paragraph 00379
[5] Patent: US2007/99930, 2007, A1. Location in patent: Page/Page column 45 |
| | 2-Amino-5-Acetylpyridine Preparation Products And Raw materials |
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