1,3-Dioxolo[4,5-c]pyridine-6-carboxamide, N-[3-[(2S,5R)-6-amino-5-(ethylsulfonyl)-2-(fluoromethyl)-2,3,4,5-tetrahydro-5-methyl-2-pyridinyl]-4-fluorophenyl]-2,2-difluoro-

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1,3-Dioxolo[4,5-c]pyridine-6-carboxamide, N-[3-[(2S,5R)-6-amino-5-(ethylsulfonyl)-2-(fluoromethyl)-2,3,4,5-tetrahydro-5-methyl-2-pyridinyl]-4-fluorophenyl]-2,2-difluoro- Suppliers list
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1,3-Dioxolo[4,5-c]pyridine-6-carboxamide, N-[3-[(2S,5R)-6-amino-5-(ethylsulfonyl)-2-(fluoromethyl)-2,3,4,5-tetrahydro-5-methyl-2-pyridinyl]-4-fluorophenyl]-2,2-difluoro- Basic information
Product Name:1,3-Dioxolo[4,5-c]pyridine-6-carboxamide, N-[3-[(2S,5R)-6-amino-5-(ethylsulfonyl)-2-(fluoromethyl)-2,3,4,5-tetrahydro-5-methyl-2-pyridinyl]-4-fluorophenyl]-2,2-difluoro-
Synonyms:1,3-Dioxolo[4,5-c]pyridine-6-carboxamide, N-[3-[(2S,5R)-6-amino-5-(ethylsulfonyl)-2-(fluoromethyl)-2,3,4,5-tetrahydro-5-methyl-2-pyridinyl]-4-fluorophenyl]-2,2-difluoro-;JNJ-67569762
CAS:2380313-26-6
MF:C22H22F4N4O5S
MW:530.49
EINECS:
Product Categories:
Mol File:2380313-26-6.mol
1,3-Dioxolo[4,5-c]pyridine-6-carboxamide, N-[3-[(2S,5R)-6-amino-5-(ethylsulfonyl)-2-(fluoromethyl)-2,3,4,5-tetrahydro-5-methyl-2-pyridinyl]-4-fluorophenyl]-2,2-difluoro- Structure
1,3-Dioxolo[4,5-c]pyridine-6-carboxamide, N-[3-[(2S,5R)-6-amino-5-(ethylsulfonyl)-2-(fluoromethyl)-2,3,4,5-tetrahydro-5-methyl-2-pyridinyl]-4-fluorophenyl]-2,2-difluoro- Chemical Properties
density 1.56±0.1 g/cm3(Predicted)
pka9.84±0.70(Predicted)
Safety Information
MSDS Information
1,3-Dioxolo[4,5-c]pyridine-6-carboxamide, N-[3-[(2S,5R)-6-amino-5-(ethylsulfonyl)-2-(fluoromethyl)-2,3,4,5-tetrahydro-5-methyl-2-pyridinyl]-4-fluorophenyl]-2,2-difluoro- Usage And Synthesis
UsesJNJ-67569762 is a selective BACE1 inhibitor targeting the S3 pocket (IC50 = 2.7 nM).
References[1] Rombouts FJR, et al. JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate. J Med Chem. 2021 Oct 14;64(19):14175-14191. DOI:10.1021/acs.jmedchem.1c00935
1,3-Dioxolo[4,5-c]pyridine-6-carboxamide, N-[3-[(2S,5R)-6-amino-5-(ethylsulfonyl)-2-(fluoromethyl)-2,3,4,5-tetrahydro-5-methyl-2-pyridinyl]-4-fluorophenyl]-2,2-difluoro- Preparation Products And Raw materials
Tag:1,3-Dioxolo[4,5-c]pyridine-6-carboxamide, N-[3-[(2S,5R)-6-amino-5-(ethylsulfonyl)-2-(fluoromethyl)-2,3,4,5-tetrahydro-5-methyl-2-pyridinyl]-4-fluorophenyl]-2,2-difluoro-(2380313-26-6) Related Product Information
1,3-Dioxolo[4,5-c]pyridine-6-carboxamide, N-[3-[(2S,5R)-6-amino-5-(ethylsulfonyl)-2-(fluoromethyl)-2,3,4,5-tetrahydro-5-methyl-2-pyridinyl]-4-fluorophenyl]-2,2-difluoro- NSC 55712 Elenbecestat(E2609) 2-Pyridinecarboxamide, N-[3-[(3R,6R)-5-amino-3,6-dihydro-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methyl- LY2811376 Aloeresin D