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| | 1,2-Diamino-4,5-difluorobenzene Basic information | | Application |
| Product Name: | 1,2-Diamino-4,5-difluorobenzene | | Synonyms: | 2-AMINO-4,5-DIFLUOROPHENYLAMINE;4,5-Difluoro-1,2-benzenediamine;4,5-Difluoro-o-phenylenediamine;1,2-Diamino-4,5-difluorobenzene;4,5-Difluoro-2-PhenylenediaMine;4,5-Difluoro-2-PhenylenediaMin;4,5-Difluorophenylene-1,2-diamine;4,5-Difluorophenylene-1,2-diamine, 1,2-Diamino-4,5-difluorobenzene | | CAS: | 76179-40-3 | | MF: | C6H6F2N2 | | MW: | 144.12 | | EINECS: | 616-301-0 | | Product Categories: | | | Mol File: | 76179-40-3.mol |  |
| | 1,2-Diamino-4,5-difluorobenzene Chemical Properties |
| Melting point | 132 °C | | Boiling point | 282.2±35.0 °C(Predicted) | | density | 1.407±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | powder to crystal | | pka | 3.51±0.10(Predicted) | | color | White to Brown | | InChI | InChI=1S/C6H6F2N2/c7-3-1-5(9)6(10)2-4(3)8/h1-2H,9-10H2 | | InChIKey | PPWRHKISAQTCCG-UHFFFAOYSA-N | | SMILES | C1(N)=CC(F)=C(F)C=C1N |
| Risk Statements | 36/37/39 | | Safety Statements | 24-36/37 | | WGK Germany | WGK 3 | | HS Code | 29215900 | | Storage Class | 11 - Combustible Solids |
| | 1,2-Diamino-4,5-difluorobenzene Usage And Synthesis |
| Application | 4,5-Difluorobenzene-1,2-diamine is an organic synthesis intermediate and a chemical and pharmaceutical intermediate, which can be used in the research and development of organic synthesis reactions in laboratories and in the research and development of chemical and pharmaceutical products. | | Chemical Properties | White powder | | Synthesis | General procedure for the synthesis of 4,5-difluorophthalimide from 2-nitro-4,5-difluoroaniline: 4,5-difluoro-2-nitroaniline (10 g, 57 mmol) was co-suspended in methanol (150 mL) with 10% palladium carbon catalyst (2.0 g, 1.9 mmol). The reaction system was transferred to a hydrogenation unit and the catalytic hydrogenation reaction was carried out under 50 psi hydrogen pressure. After 3 hours of reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to give a solid product. The resulting solid was dried under vacuum at room temperature overnight to obtain white crystalline 4,5-difluorophthalimide (8.05 g, 98% yield). | | References | [1] Journal of Medicinal Chemistry, 1993, vol. 36, # 3, p. 331 - 342
[2] Patent: US2005/43292, 2005, A1. Location in patent: Page/Page column 14
[3] Patent: EP2766359, 2016, B1. Location in patent: Paragraph 0755
[4] Journal of Medicinal Chemistry, 1997, vol. 40, # 5, p. 811 - 818
[5] Russian Journal of Organic Chemistry, 2001, vol. 37, # 4, p. 564 - 569 |
| | 1,2-Diamino-4,5-difluorobenzene Preparation Products And Raw materials |
| Raw materials | 4,5-Difluoro-2-nitroaniline-->Iron-->Methanol-->Hydrogen | | Preparation Products | 4,7-Bis(5-broMothiophen-2-yl)-5,6-difluorobenzo[c][1,2,5] thiadiazole-->1H-Benzimidazol-2-amine,5,6-difluoro-(9CI)-->2H-Benzimidazol-2-one,5,6-difluoro-1,3-dihydro-,hydrazone(9CI) |
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