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| | (S)-2-(Aminoethyl)-1-N-Boc-pyrrolidine Basic information |
| Product Name: | (S)-2-(Aminoethyl)-1-N-Boc-pyrrolidine | | Synonyms: | (S)-tert-butyl 2-(2-aminoethyl)pyrrolidine-1-carboxylate;tert-butyl (2S)-2-(2-aMinoethyl)pyrrolidine-1-carboxylate;2-Ethyl-pyrrolidine-1-carboxylic acid tert-butyl ester;tert-Butyl (2S)-2-(2-aminoethyl)-1-pyrrolidinecarboxylate;1-Pyrrolidinecarboxylic acid, 2-(2-aminoethyl)-, 1,1-dimethylethyl ester, (2S)-;(S)-2-(Aminoethyl)-1-Boc-pyrrolidine;(S)-1-Boc-2-(2-aminoethyl)pyrrolidine;(S)-2-(Aminoethyl)-1-Boc-pyrrolidine - [A14053] | | CAS: | 239483-09-1 | | MF: | C11H22N2O2 | | MW: | 214.3 | | EINECS: | | | Product Categories: | | | Mol File: | 239483-09-1.mol |  |
| | (S)-2-(Aminoethyl)-1-N-Boc-pyrrolidine Chemical Properties |
| Boiling point | 297.5±13.0 °C(Predicted) | | density | 1.029 | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 10.27±0.10(Predicted) | | Appearance | light yellow liquid |
| RIDADR | UN3077 | | HazardClass | 8 |
| | (S)-2-(Aminoethyl)-1-N-Boc-pyrrolidine Usage And Synthesis |
| Synthesis | Step d: Synthesis of tert-butyl (S)-2-(2-aminoethyl)pyrrolidine-1-carboxylate. The product of step c, tert-butyl (S)-2-(cyanomethyl)pyrrolidine-1-carboxylate (1.45 g, 6.9 mmol) was suspended in ammonia saturated methanol (50 ml) and Raney-Nickel (ca. 1.0 g) and hexachloroplatinic acid (IV) hydrate (80 mg dissolved in 1 ml of water) were added. The mixture was placed in a Parr reaction flask and stirred under hydrogen pressure (~40 psi) for 24 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was evaporated. The crude product was purified by fast chromatography (eluent: dichloromethane:methanol:ammonia (880) 90:10:1) to afford tert-butyl (S)-2-(2-aminoethyl)pyrrolidine-1-carboxylate (1.18 g, 80% yield).1H NMR (CDCl3) δ: 3.90 (1H, m), 3.30 (2H, m), 2.71 (2H, t). 1.87-1.45 (17H, m). | | References | [1] Patent: EP1056733, 2004, B1. Location in patent: Page 34-35
[2] Patent: WO2006/116764, 2006, A1. Location in patent: Page/Page column 121; 133-134
[3] Tetrahedron Letters, 1994, vol. 35, # 47, p. 8805 - 8808
[4] Patent: WO2004/58705, 2004, A2. Location in patent: Page 40-42
[5] Organic and Biomolecular Chemistry, 2010, vol. 8, # 16, p. 3742 - 3750 |
| | (S)-2-(Aminoethyl)-1-N-Boc-pyrrolidine Preparation Products And Raw materials |
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