YAP/TAZinhibitor2 manufacturers
- YAP/TAZ inhibitor-2
-
-
2026-08-26
- CAS:2762617-31-0
- Min. Order: 1KG
- Purity: 98
- Supply Ability: 1000 KG
|
| | YAP/TAZinhibitor2 Basic information |
| Product Name: | YAP/TAZinhibitor2 | | Synonyms: | YAP/TAZ inhibitor-2;YAP/TAZinhibitor2;2-Propen-1-one, 2-fluoro-1-[3-[3-[4-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridin-1-yl]-1-azetidinyl]-;YAP/TAZ inhibitor-2u00A0;2-Fluoro-1-(3-(3-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)azetidin-1-yl)prop-2-en-1-one;YAP/TAZ inhibitor-2u00A0, 10 mM in DMSO | | CAS: | 2762617-31-0 | | MF: | C19H14F4N4O | | MW: | 390.33 | | EINECS: | | | Product Categories: | | | Mol File: | 2762617-31-0.mol |  |
| | YAP/TAZinhibitor2 Chemical Properties |
| Boiling point | 559.9±50.0 °C(Predicted) | | density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (256.19 mM; Need ultrasonic) | | pka | 2.50±0.30(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | YAP/TAZinhibitor2 Usage And Synthesis |
| Uses | YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity[1]. | | Biological Activity | YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity[1].
YAP/TAZ inhibitor-2 (compound 5) (0-20000 nM; 24 h) shows antiproliferative activity with an IC50 value of 5.33 nM in NCI-H226 cells[1].
YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) shows anti-tumor activity with no significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model)[1]. | | in vivo | YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) shows anti-tumor activity with no significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model)[1]. | | IC 50 | YAP/TAZ-TEAD | | References | [1]. Xu, xiaofeng, et al. Bicyclic compounds, compositions and use thereof. WO2022037568A1. |
| | YAP/TAZinhibitor2 Preparation Products And Raw materials |
|