BQ-3020 manufacturers
- BQ-3020
-
- $7.00
-
2020-02-14
- CAS:143113-45-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
|
| | BQ-3020 Basic information |
| Product Name: | BQ-3020 | | Synonyms: | N-AC, ALA11,15-ENDOTHELIN 1, 6-21;N-ACETYL[ALA11,15]-ENDOTHELIN-1 (6-21);N-ACETYL-[ALA11,15]ENDOTHELIN-I (6-21);AC-(ALA11,15)-ENDOTHELIN-1 (6-21);BQ-3020;ENDOTHELIN-1(6-21), N-ACETYL-[ALA11,15]-;Acetyl-(Ala11·15)-Endothelin-1 (6-21) Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH;ACETYL-(ALA11,15)-ENDOTHELIN-1 (6-21) | | CAS: | 143113-45-5 | | MF: | C96H140N20O25S | | MW: | 2006.34 | | EINECS: | | | Product Categories: | Endothelin receptor | | Mol File: | 143113-45-5.mol |  |
| | BQ-3020 Chemical Properties |
| Boiling point | 2125.8±65.0 °C(Predicted) | | density | 1.287±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | Soluble to 0.50 mg/ml in sodium bicarbonate (0.03M) | | form | powder | | pka | 3.39±0.10(Predicted) | | color | white | | Sensitive | Light Sensitive | | Sequence | Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH | | InChIKey | NUAGCEFLVCODRQ-KETPNHLCSA-N |
| WGK Germany | 3 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 1 Inhalation
Acute Tox. 1 Oral |
| | BQ-3020 Usage And Synthesis |
| Uses | BQ-3020 is a selective endothelin receptor (ETB receptor) agonist that displaces [125I] ET-1 binding to ETB receptors, with an IC50 value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research12. | | Biological Activity | BQ-3020, a linear endothelin analog, is a selective ETB endothelin receptor agonist. | | in vivo | BQ-3020 (3 mg/kg for i.h., single dose) attenuates cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection in cancer pain mouse model[3].
| Animal Model: | Cancer pain mouse model [3] | | Dosage: | 3 mg/kg | | Administration: | Injected subcutaneously at the site of the greatest tumor development | | Result: | Attenuated cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection
|
| | IC 50 | ETB: 0.2 nM (IC50) | | storage | -20°C | | References | [1] Arteaga JL,et.al. Endothelin ET(B) receptors are involved in the relaxation to the pig urinary bladder neck. Neurourol Urodyn. 2012 Jun;31(5):688-94. DOI:10.1002/nau.22203
[2] Ihara M, et.al. A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptors. Life Sci. 1992;51(6):PL47-52. DOI:10.1016/0024-3205(92)90418-o
[3] Quang PN, et.al. Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice. Pain. 2010 May;149(2):254-262. DOI:10.1016/j.pain.2010.02.009 |
| | BQ-3020 Preparation Products And Raw materials |
|