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| | N-2-Pyridinyl-1,2-ethanediamine Basic information |
| | N-2-Pyridinyl-1,2-ethanediamine Chemical Properties |
| Melting point | 45-47°C | | Boiling point | 93-95°C/0.5 Torr | | density | 1.121±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | pka | 9.19±0.10(Predicted) |
| | N-2-Pyridinyl-1,2-ethanediamine Usage And Synthesis |
| Chemical Properties | Light Yellow Oil | | Uses | N-2-Pyridinyl-1,2-ethanediamine is a reactant used in the synthesis of dual histamine H1 and H2 receptor antagonists based on cyanoguanidine. Also used in the synthesis of 2-thiohydantoins as somatostatin receptor ligands, | | Synthesis | The reaction was carried out with 2-bromopyridine and ethylenediamine with reference to the literature method (11a) to obtain the target product N1-(pyridin-2-yl)ethane-1,2-diamine, which was a light yellow liquid in 85.34% yield. | | References | [1] Patent: CN105541777, 2016, A. Location in patent: Paragraph 0016; 0077; 0078; 0079
[2] European Journal of Medicinal Chemistry, 1987, vol. 22, p. 91 - 100
[3] Patent: US2002/86850, 2002, A1
[4] Patent: US6610665, 2003, B1
[5] Patent: EP1051425, 2002, B1 |
| | N-2-Pyridinyl-1,2-ethanediamine Preparation Products And Raw materials |
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