Olean-12-en-28-amide, 2-methylene-3-oxo-N-2-propen-1-yl-

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Company Name: TargetMol Chemicals Inc.  
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Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

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Olean-12-en-28-amide, 2-methylene-3-oxo-N-2-propen-1-yl- Basic information
Product Name:Olean-12-en-28-amide, 2-methylene-3-oxo-N-2-propen-1-yl-
Synonyms:Olean-12-en-28-amide, 2-methylene-3-oxo-N-2-propen-1-yl-;PI3K/Akt/mTOR-IN-3
CAS:2457245-94-0
MF:C34H51NO2
MW:505.77
EINECS:
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Mol File:2457245-94-0.mol
Olean-12-en-28-amide, 2-methylene-3-oxo-N-2-propen-1-yl- Structure
Olean-12-en-28-amide, 2-methylene-3-oxo-N-2-propen-1-yl- Chemical Properties
Boiling point 615.3±55.0 °C(Predicted)
density 1.05±0.1 g/cm3(Predicted)
pka15.89±0.70(Predicted)
Safety Information
MSDS Information
Olean-12-en-28-amide, 2-methylene-3-oxo-N-2-propen-1-yl- Usage And Synthesis
UsesPI3K/Akt/mTOR-IN-3 (compound 3d) is a potent PI3K/AKT/mTOR inhibitor. PI3K/Akt/mTOR-IN-3 displays the inhibitory activity in MCF-7, HeLa and HepG2 cells, with IC50 values of 0.77, 1.23, and 4.57μM, respectively. PI3K/Akt/mTOR-IN-3 inhibits the migration of MCF-7 and HeLa cells at the concentration of 4 μM. PI3K/Akt/mTOR-IN-3 induces cell apoptosis and S phase arrest[1].
References[1] Wang SS, et al. Synthesis and antitumor activity of α,β-unsaturated carbonyl moiety- containing oleanolic acid derivatives targeting PI3K/AKT/mTOR signaling pathway. Bioorg Chem. 2020 Aug;101:104036. DOI:10.1016/j.bioorg.2020.104036
Olean-12-en-28-amide, 2-methylene-3-oxo-N-2-propen-1-yl- Preparation Products And Raw materials
Tag:Olean-12-en-28-amide, 2-methylene-3-oxo-N-2-propen-1-yl-(2457245-94-0) Related Product Information
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