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| | BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT Basic information |
| Product Name: | BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT | | Synonyms: | THR-SER-LYS;BOVINE PINEAL ANTIREPRODUCTIVE PEPTIDE;BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE;BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT;H-THR-SER-LYS-OH ACETATE SALT;H-Thr-Ser-Lys-OH;thr-ser-lys acetate;threonyl-seryl-lysine | | CAS: | 71730-64-8 | | MF: | C13H26N4O6 | | MW: | 334.37 | | EINECS: | | | Product Categories: | | | Mol File: | 71730-64-8.mol |  |
| | BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT Chemical Properties |
| | BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT Usage And Synthesis |
| Uses | Threonyl-seryl-lysine, a bovine pineal antireproductive tripeptide, has antigonadotropic activity. Threonyl-seryl-lysine binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5[1][3]. | | Definition | ChEBI: Thr-Ser-Lys is an oligopeptide. | | in vivo | Threonyl-seryl-lysine (175 ng, i.p.) reduces the 5-day compensatory ovarian hypertrophy in unilaterally ovariectomized (UO) mice[1].
Threonyl-seryl-lysine (1 or 5 μg, i.p.) delays vaginal opening time in female Charles River CD rats[2].
Threonyl-seryl-lysine (1 and 10 μg, s.c., for 15 days) increases the weight of ovaries and of adrenals in mice[4].
| Animal Model: | Unilaterally ovariectomized (UO) mice | | Dosage: | 175 ng | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Reduced serum follicle stimulating hormone (FSH) in UO mice. |
| | References | [1] Orts RJ, et al. Inhibitory properties of a bovine pineal tripeptide, threonylseryllysine, on serum follicle-stimulating hormone. Neuroendocrinology. 1980 Aug;31(2):92-5. DOI:10.1159/000123056
[2] Benson B. Bovine pineal tripeptide threonylseryllysine retards puberty in female rats. J Pineal Res. 1989;6(4):351-7. DOI:10.1111/j.1600-079x.1989.tb00431.x
[3] Root-Bernstein RS, et al. Bovine pineal antireproductive tripeptide binds to luteinizing hormone-releasing hormone: a model for peptide modulation by sequence specific peptide interactions Brain Res Bull. 1986 Oct;17(4):519-28. DOI:10.1016/0361-9230(86)90219-4
[4] Vaughan M K, et al. Influence of Thr-Ser-Lys (TSL), a recently isolated pineal peptide, on ovarian and uterine weights and estrous cycles in mice, hamsters and rats. Pineal function (Mathews CD, Seamark RF, eds.), 1981: 165-172. |
| | BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT Preparation Products And Raw materials |
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