| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
marketing1@energy-chemical.com |
PNU 109291 manufacturers
- PNU109291
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- $3080.00
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2026-05-21
- CAS:187665-60-7
- Purity:
- Supply Ability: 10g
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| | PNU 109291 Basic information |
| Product Name: | PNU 109291 | | Synonyms: | PNU 109291;(S)-3,4-DIHYDRO-1-[2-[4-(4-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE;1H-2-Benzopyran-6-carboxamide, 3,4-dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-, (1S)- | | CAS: | 187665-60-7 | | MF: | C24H31N3O3 | | MW: | 409.52 | | EINECS: | | | Product Categories: | | | Mol File: | 187665-60-7.mol |  |
| | PNU 109291 Chemical Properties |
| Boiling point | 595.8±50.0 °C(Predicted) | | density | 1.143±0.06 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol | | form | Powder | | pka | 15.27±0.40(Predicted) |
| | PNU 109291 Usage And Synthesis |
| Uses | PNU 109291 is a 5-HT receptor agonist. | | Biological Activity | Potent and selective 5-HT 1D receptor agonist that displays > 600-fold selectivity over 5-HT 1A and 5-HT 2A receptors and no activity at 5-HT 1B , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 6 and 5-HT 7 receptors. Reduces dural plasma extravasation evoked by trigeminal ganglion stimulation. | | in vivo | PNU109291 (0.24, 2.4, 7.3, 24.4, 73.3 nmol/kg; s.c.) reduces dural plasma extravasation evoked by trigeminal ganglion stimulation in pigs[1].
PNU109291 (3 μM) inhibited evoked EPSCs (excitatory postsynaptic currents) in Freund's adjuvant (CFA) but not saline-injected rats[2]. | Animal Model: | 200-500g, male Hartley guinea pigs[1] | | Dosage: | 0.24, 2.4, 7.3, 24.4, 73.3 nmol/kg | | Administration: | S.c.; 60 min before electrical stimulation | | Result: | Dose-dependently decreased plasma protein extravasation with an IC50 value of 4.2 nmol/kg. |
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| | PNU 109291 Preparation Products And Raw materials |
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