| Company Name: |
Lynnchem |
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86-(0)29-85992781 17792393971 |
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info@lynnchem.com |
| Company Name: |
Novachemistry |
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info@novachemistry.com |
- Quinaldopeptin
-
- $1420.00
-
2025-12-22
- CAS:130743-07-6
- Purity:
- Supply Ability: 10g
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| | quinaldopeptin Basic information |
| | quinaldopeptin Chemical Properties |
| density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: soluble; DMSO: soluble; Ethanol: slightly soluble; Methanol: slightly soluble | | form | Yellow powder. | | pka | 6.91±0.40(Predicted) |
| | quinaldopeptin Usage And Synthesis |
| Description | Quinaldopeptin is a quinomycin antibiotic. It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1, and 6.3 μg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 μg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM). | | Uses | Quinaldopeptin is a symmetrical, cyclic decapeptide from an Amycolatopsis sp. that is a bis-intercalator of DNA, exhibiting strong in vitro antimicrobial and cytotoxic activity. Quinaldopeptin significantly prolongs the survival time of mice inoculated with a murine tumour, and also shows weak nematocidal activity. Quinaldopeptin is related to the luzopeptins and sandramycin. | | Uses | Quinaldopeptin is a bis-intercalating cyclic peptide antibiotic. | | in vivo | Quinaldopeptin shows slight prolongation of life-span in P388-bearing mice at 0.03~0.01 mg/kg, but the antitumor activities is quite limited[1]. | | References | [1] S TODA. Quinaldopeptin, a novel antibiotic of the quinomycin family.[J]. Journal of Antibiotics, 1990, 43 7: 796-808. DOI: 10.7164/antibiotics.43.796
[2] ANOKHAS. RATNAYAKE. Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody–Drug Conjugates[J]. Bioconjugate Chemistry Bioconjugate, 2018, 30 1: 200-209. DOI: 10.1021/acs.bioconjchem.8b00843 |
| | quinaldopeptin Preparation Products And Raw materials |
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