(2-(2-(2-((2-bromoacetyl)amino)ethoxy)ethoxy)ethoxy)acetic acid

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(2-(2-(2-((2-bromoacetyl)amino)ethoxy)ethoxy)ethoxy)acetic acid Basic information
Product Name:(2-(2-(2-((2-bromoacetyl)amino)ethoxy)ethoxy)ethoxy)acetic acid
Synonyms:(2-(2-(2-((2-bromoacetyl)amino)ethoxy)ethoxy)ethoxy)acetic acid;Acetic acid, 2-[2-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]ethoxy]-;Bromoacetamide-PEG3-C1-acid
CAS:173323-22-3
MF:C10H18BrNO6
MW:328.16
EINECS:
Product Categories:
Mol File:173323-22-3.mol
(2-(2-(2-((2-bromoacetyl)amino)ethoxy)ethoxy)ethoxy)acetic acid Structure
(2-(2-(2-((2-bromoacetyl)amino)ethoxy)ethoxy)ethoxy)acetic acid Chemical Properties
Boiling point 539.5±50.0 °C(Predicted)
density 1.449±0.06 g/cm3(Predicted)
pka3.39±0.10(Predicted)
Safety Information
MSDS Information
(2-(2-(2-((2-bromoacetyl)amino)ethoxy)ethoxy)ethoxy)acetic acid Usage And Synthesis
UsesBromoacetamide-PEG3-C1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biological ActivityBromoacetamide-PEG3-C1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
IC 50PEGs
References[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
(2-(2-(2-((2-bromoacetyl)amino)ethoxy)ethoxy)ethoxy)acetic acid Preparation Products And Raw materials
Tag:(2-(2-(2-((2-bromoacetyl)amino)ethoxy)ethoxy)ethoxy)acetic acid(173323-22-3) Related Product Information
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