| Company Name: |
Wuxi AppTec |
| Tel: |
022-59987777 13552403979 |
| Email: |
jia_guoqiang@wuxiapptec.com |
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| | tibenelast Basic information |
| Product Name: | tibenelast | | Synonyms: | tibenelast;5,6-Diethoxybenzo[b]thiophene-2-carboxylic acid;LY-186655;Benzo[b]thiophene-2-carboxylic acid, 5,6-diethoxy- | | CAS: | 97852-72-7 | | MF: | C13H14O4S | | MW: | 266.31 | | EINECS: | | | Product Categories: | | | Mol File: | 97852-72-7.mol |  |
| | tibenelast Chemical Properties |
| Boiling point | 440.8±40.0 °C(Predicted) | | density | 1.289±0.06 g/cm3(Predicted) | | pka | 3.54±0.30(Predicted) |
| | tibenelast Usage And Synthesis |
| Uses | Tibenelast (LY186655) free acid is a potent and orally active is a phosphodiesterase inhibitor. Tibenelast free acid is an anti-asthma agent Tibenelast free acid increases the heart rate response to isoproterenol (HY-108353). Tibenelast free acid shows anti-anaphylactic shock activity. Tibenelast free acid has the potential for the research of asthma and other respiratory diseases[1][2]. | | References | [1] Ho PP, et al. Tibenelast, 5,6-diethoxybenzo(B)thiophene-2-carboxylic acid, sodium salt (LY186655), is an orally active anti-asthma compound in the guinea pig. Life Sci. 1990;46(13):917-25. DOI:10.1016/0024-3205(90)90093-7
[2] Schwertschlag US, et al. Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol-stimulated heart rate, cyclic AMP and norepinephrine levels. Pharmacology. 1993;46(3):142-7. DOI:10.1159/000139039 |
| | tibenelast Preparation Products And Raw materials |
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