LAVENDUSTIN C

Request For Quotation
LAVENDUSTIN C Suppliers list
Company Name: J & K SCIENTIFIC LTD.  
Tel: 18210857532 18210857532
Email: jkinfo@jkchemical.com
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 18930552037
Email: 3bsc@sina.com
Company Name: VDM Biochemicals   
Tel: 0330-2528181
Email: sales@vdmbio.com
Company Name: Chemsky（shanghai）International Co.,Ltd.  
Tel: 021-50135380
Email: shchemsky@sina.com
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
LAVENDUSTIN C Basic information
Product Name:LAVENDUSTIN C
Synonyms:2-HYDROXY-5-(2,5-DIHYDROXYBENZYLAMINO)BENZOIC ACID;[2-HYDROXY-5-[N-(2',5'-DIHYDROXYBENZYL)AMINO]BENZOIC ACID;5-(2,5-DIHYDROXYBENZYLAMINO)-2-HYDROXYBENZOIC ACID;5-(2,5-DIHYDROXYBENZYLAMINO)SALICYLIC ACID;5-(N-2',5'-DIHYDROXYBENZYL)AMINOSALICYLIC ACID;5-(N-2,5-DIHYDROXYBENZYL)AMINOSALICYLIC ACID;HDBA;LAVENDUSTIN C
CAS:125697-93-0
MF:C14H13NO5
MW:275.26
EINECS:
Product Categories:Other enzyme inhibitors and activators;All Inhibitors;Inhibitors;Tyrosine Kinase Inhibitors
Mol File:125697-93-0.mol
LAVENDUSTIN C Structure
LAVENDUSTIN C Chemical Properties
Melting point 193-195°C dec.
Boiling point 597.5±50.0 °C(Predicted)
density 1.551±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility DMSO: soluble
form solid
pka2.32±0.10(Predicted)
color Light Beige to Brown
Stability:Hygroscopic
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
F 3-10
MSDS Information
ProviderLanguage
SigmaAldrich English
LAVENDUSTIN C Usage And Synthesis
DescriptionLavendustin C, a derivative of a Streptomyces griseolavendus butyl acetate extract, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC50 value of 0.012 μM. Lavendustin C also inhibits pp60c-src(+) kinase and Ca2+ calmodulin-dependent kinase II with IC50 values of 0.5 and 0.2 μM, respectively. At a concentration of 10-150 μM, lavendustin C inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation.
Chemical PropertiesBrown Solid
UsesShows potent tyrosine kinase inhibitory activity.
DefinitionChEBI: 5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxybenzoic acid is an aromatic amine.
IC 50CaMK II: 0.2 μM (IC50); EGFR: 0.012 μM (IC50)
References[1] HELEN M. BURT  Hassan S  John K Jackson. Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor[J]. Journal of Leukocyte Biology, 1994, 55 1: 112-119. DOI: 10.1002/jlb.55.1.112
LAVENDUSTIN C Preparation Products And Raw materials
Tag:LAVENDUSTIN C(125697-93-0) Related Product Information
Lavendustin a methyl ester 5-Aminosalicylic acid Salicylic acid Lavendustin C Analog, Methyl-4-[N-(2μ,5μ-dihydroxybenzyl)amino]benzoate,LAVENDUSTIN C ANALOG LAVENDUSTIN B lavendustin C6 5-BENZYL-2-FURALDEHYDE LAVENDUSTIN C LAVENDUSTIN C METHYL ESTER LAVENDUSTIN A