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| | Leo 271 f Basic information |
| Product Name: | Leo 271 f | | Synonyms: | Leo 271 f;Bis(2-chloroethyl)carbamic acid 17-oxoestra-1,3,5(10)-trien-3-yl ester;Estromustine;(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl bis(2-chloroethyl)carbamate;Estra-1,3,5(10)-trien-17-one, 3-[[[bis(2-chloroethyl)amino]carbonyl]oxy]-;[(8R,9S,13S,14S)-13-Methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl]n,N-bis(2-chloroethyl)carbamate | | CAS: | 62899-40-5 | | MF: | C23H29Cl2NO3 | | MW: | 438.39 | | EINECS: | | | Product Categories: | | | Mol File: | 62899-40-5.mol |  |
| | Leo 271 f Chemical Properties |
| Boiling point | 564.7±50.0 °C(Predicted) | | density | 1.249±0.06 g/cm3(Predicted) | | pka | -1.88±0.70(Predicted) |
| | Leo 271 f Usage And Synthesis |
| Uses | Estromustine (EoM) is the active metabolite of Estramustine phosphate (HY-13627A). Estromustine binds to mutant androgen receptor (m-AR) with EC50 of 2.6 μM in LNCaP, exhibits cytotoxicity in human prostate cells LNCaP with IC50 of 9.73 μM[1]. | | References | [1] Wang LG, et al., Androgen antagonistic effect of estramustine phosphate (EMP) metabolites on wild-type and mutated androgen receptor. Biochem Pharmacol. 1998 May 1;55(9):1427-33. DOI:10.1016/s0006-2952(97)00657-6 |
| | Leo 271 f Preparation Products And Raw materials |
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