1-acetyl-3,2-toluyl-5-fluorouracil
| 中文名称 | 1-acetyl-3,2-toluyl-5-fluorouracil |
|---|---|
| 中文同义词 | 化合物 T10013;化合物 1-ACETYL-3-O-TOLUYL-5-FLUOROURACIL |
| 英文名称 | 1-acetyl-3,2-toluyl-5-fluorouracil |
| 英文同义词 | 1-acetyl-3,2-toluyl-5-fluorouracil;1-Acetyl-3-o-toluyl-5-fluorouracil;A-?OT-?Fu;2,4(1H,3H)-Pyrimidinedione, 1-acetyl-5-fluoro-3-(2-methylbenzoyl)-;1 Acetyl 3 o toluyl 5 fluorouracil,1Acetyl3otoluyl5fluorouracil |
| CAS号 | 71861-76-2 |
| 分子式 | C14H11FN2O4 |
| 分子量 | 290.25 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 71861-76-2.mol |
| 结构式 |  |
1-acetyl-3,2-toluyl-5-fluorouracil 性质
| 熔点 | 141-143 °C(Solv: ethyl ether (60-29-7)) |
|---|---|
| 沸点 | 408.8±55.0 °C(Predicted) |
| 密度 | 1.44±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | -5.29±0.40(Predicted) |
1-Acetyl-3-o-toluyl-5-fluorouracil是有效的抗肿瘤剂。
Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d).