Biofor 389 manufacturers
- Biofor 389
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- $156.00
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2026-07-13
- CAS:127245-22-1
- Purity: 99.71%
- Supply Ability: 10g
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| | Biofor 389 Basic information |
| Product Name: | Biofor 389 | | Synonyms: | Biofor 389;2H-1,2-Oxazin-3(4H)-one, 4-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-2-methyl-;BF 389;4-[(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]-2-methyl-1,2-oxazinan-3-one | | CAS: | 127245-22-1 | | MF: | C20H29NO3 | | MW: | 331.45 | | EINECS: | | | Product Categories: | | | Mol File: | 127245-22-1.mol |  |
| | Biofor 389 Chemical Properties |
| Melting point | 171-172 °C | | Boiling point | 409.2±55.0 °C(Predicted) | | density | 1.088±0.06 g/cm3(Predicted) | | pka | 11.68±0.50(Predicted) |
| | Biofor 389 Usage And Synthesis |
| Uses | BF389 (Biofor 389) is an orally active anti-inflammatory and analesis agent. BF389 is also an inhibitor of cyclooxygenase and 5-lipoxygenase, with IC50s of 4 and 8 ug/mL for COX-1 and COX-2 respectively. BF389 can be used for arthritis research[1][2][3]. | | in vivo | BF389 (1-30 mg/kg, p.o., five daily oral doses) inhibits paw swelling in rats, with an ED50 of 4.9 mg/kg, indicating the anti-inflammatory activity[1].
| | IC 50 | COX-1: 4 μg/mL (IC50); COX-2: 8 μg/mL (IC50); 5-LOX | | References | [1] Bendele AM, et al. Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis. J Pharmacol Exp Ther. 1992 Jan;260(1):300-5. PMID:1309875
[2] Wong S, et al. Antiarthritic profile of BF-389--a novel anti-inflammatory agent with low ulcerogenic liability. Agents Actions. 1992 Sep;37(1-2):90-8. DOI:10.1007/BF01987895
[3] Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. DOI:10.1073/pnas.90.24.11693 |
| | Biofor 389 Preparation Products And Raw materials |
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