143943-72-0
| 中文名称 | 143943-72-0 |
|---|---|
| 中文同义词 | 化合物 T12763;化合物 RO 41-3290 |
| 英文名称 | Ro 41-3290 |
| 英文同义词 | Ro 41-3290;3-Pyrrolidinol, 1-[(10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizin-1-yl)carbonyl]-, (3S)- (9CI);Ro 41 3290,Ro 413290 |
| CAS号 | 143943-72-0 |
| 分子式 | C24H21ClN2O3 |
| 分子量 | 420.89 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 143943-72-0.mol |
| 结构式 |  |
143943-72-0 性质
| 沸点 | 723.3±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.44±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 14.47±0.20(Predicted) |
Benzodiazepine receptor
At all times plasma levels of Ro 41-3290, the desethylated derivative of Ro 41-3696, are higher than those of the parent drug (t max and t 1/2 values=~2 and 8 hours, respectively). Pharmacokinetics of both Ro 41-3696 and its O-desethyl metabolite Ro 41-3290 are dose proportional and time independent. Ro 41-3696 is absorbed and eliminates rapidly (time of maximum plasma concentration, approximately 1 hour; elimination half-life, approximately 2 hours). Plasma levels of Ro 41-3290 are higher than those of the parent drug, and it is more slowly eliminated (values for time of maximum plasma concentration and elimination half-life, approximately 2 and approximately 7 hours, respectively).