Ro 41-3290

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Ro 41-3290 manufacturers

  • Ro 41-3290
  • Ro 41-3290 pictures
  • $1520.00
  • 2026-04-21
  • CAS:143943-72-0
  • Purity:
  • Supply Ability: 10g
  • Ro 41-3290
  • Ro 41-3290 pictures
  • $1520.00
  • 2025-08-22
  • CAS:143943-72-0
  • Purity:
  • Supply Ability: 10g
Ro 41-3290 Basic information
Product Name:Ro 41-3290
Synonyms:Ro 41-3290;3-Pyrrolidinol, 1-[(10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizin-1-yl)carbonyl]-, (3S)- (9CI);Ro 41 3290,Ro 413290
CAS:143943-72-0
MF:C24H21ClN2O3
MW:420.89
EINECS:
Product Categories:
Mol File:143943-72-0.mol
Ro 41-3290 Structure
Ro 41-3290 Chemical Properties
Boiling point 723.3±60.0 °C(Predicted)
density 1.44±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka14.47±0.20(Predicted)
Safety Information
MSDS Information
Ro 41-3290 Usage And Synthesis
UsesRo 41-3290 is the desethylated derivative of Ro 41-3696, which is a nonbenzodiazepine partial agonist at the benzodiazepine receptor.
in vivo

At all times plasma levels of Ro 41-3290, the desethylated derivative of Ro 41-3696, are higher than those of the parent drug (tmax and t1/2 values=~2 and 8 hours, respectively)[1]. Pharmacokinetics of both Ro 41-3696 and its O-desethyl metabolite Ro 41-3290 are dose proportional and time independent. Ro 41-3696 is absorbed and eliminates rapidly (time of maximum plasma concentration, approximately 1 hour; elimination half-life, approximately 2 hours). Plasma levels of Ro 41-3290 are higher than those of the parent drug, and it is more slowly eliminated (values for time of maximum plasma concentration and elimination half-life, approximately 2 and approximately 7 hours, respectively)[2].

References[1] Dingemanse J, et al. Pharmacokinetics and pharmacodynamics of Ro 41-3696, a novel nonbenzodiazepine hypnotic. J Clin Pharmacol. 1995 Aug;35(8):821-9. DOI:10.1002/j.1552-4604.1995.tb04126.x
[2] Dingemanse J, et al. Multiple-dose tolerability, pharmacodynamics, and pharmacokinetics of the quinolizinone hypnotic Ro 41-3696 in elderly subjects. Clin Neuropharmacol. 2001 Mar-Apr;24(2):82-90. DOI:10.1097/00002826-200103000-00003
Ro 41-3290 Preparation Products And Raw materials
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