4-Imidazolidinecarboxamide, N-(3-chloro-2,4-difluorophenyl)-N-methyl-3-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-2-oxo-, (4S)-

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4-Imidazolidinecarboxamide, N-(3-chloro-2,4-difluorophenyl)-N-methyl-3-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-2-oxo-, (4S)- Suppliers list
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4-Imidazolidinecarboxamide, N-(3-chloro-2,4-difluorophenyl)-N-methyl-3-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-2-oxo-, (4S)- Basic information
Product Name:4-Imidazolidinecarboxamide, N-(3-chloro-2,4-difluorophenyl)-N-methyl-3-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-2-oxo-, (4S)-
Synonyms:4-Imidazolidinecarboxamide, N-(3-chloro-2,4-difluorophenyl)-N-methyl-3-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-2-oxo-, (4S)-;PolQi1
CAS:2607139-80-8
MF:C18H14ClF5N4O2
MW:448.77
EINECS:
Product Categories:
Mol File:2607139-80-8.mol
4-Imidazolidinecarboxamide, N-(3-chloro-2,4-difluorophenyl)-N-methyl-3-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-2-oxo-, (4S)- Structure
4-Imidazolidinecarboxamide, N-(3-chloro-2,4-difluorophenyl)-N-methyl-3-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-2-oxo-, (4S)- Chemical Properties
density 1.511±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka12.04±0.40(predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
4-Imidazolidinecarboxamide, N-(3-chloro-2,4-difluorophenyl)-N-methyl-3-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-2-oxo-, (4S)- Usage And Synthesis
UsesPolQi1 is a Pol (polymerase theta) inhibitor. PolQi1 targets the polymerase domain of the enzyme[1].
References[1] Wimberger S, et al. Simultaneous inhibition of DNA-PK and Pol improves integration efficiency and precision of genome editing. Nat Commun. 2023 Aug 14;14(1):4761. DOI:10.1038/s41467-023-40344-4
4-Imidazolidinecarboxamide, N-(3-chloro-2,4-difluorophenyl)-N-methyl-3-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-2-oxo-, (4S)- Preparation Products And Raw materials
Tag:4-Imidazolidinecarboxamide, N-(3-chloro-2,4-difluorophenyl)-N-methyl-3-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-2-oxo-, (4S)-(2607139-80-8) Related Product Information
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