5-METHYL-2H-ISOQUINOLIN-1-ONE manufacturers
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| | 5-METHYL-2H-ISOQUINOLIN-1-ONE Basic information |
| Product Name: | 5-METHYL-2H-ISOQUINOLIN-1-ONE | | Synonyms: | 5-METHYL-2H-ISOQUINOLIN-1-ONE;5-Methylisoquinolin-1(2H);5-methyl-1,2-dihydroisoquinolin-1-one;5-methylisoquinolin-1(2H)-one;5-Methyl-2H-Isoquinoline-1-one;5-Methylisoquinolin-1-ol;5-methyl-1(2H)-isoquinolinone;1(2H)-Isoquinolinone, 5-methyl- | | CAS: | 24188-72-5 | | MF: | C10H9NO | | MW: | 159.18 | | EINECS: | | | Product Categories: | | | Mol File: | 24188-72-5.mol |  |
| | 5-METHYL-2H-ISOQUINOLIN-1-ONE Chemical Properties |
| Boiling point | 400.5±45.0 °C(Predicted) | | density | 1.150±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 13.12±0.20(Predicted) | | Appearance | Light yellow to yellow Solid |
| | 5-METHYL-2H-ISOQUINOLIN-1-ONE Usage And Synthesis |
| Synthesis | Synthesis of Intermediate-3: 5-Methylisoquinolin-1(2H)-one: o-Methylcinnamoyl azide (Intermediate-2) (10 g, 53.5 mmol) was dissolved in toluene (100 mL) with stirring and heated to 110±2°C for 1 hour. After completion of the reaction, the toluene solvent was removed under reduced pressure, 1,2-dichlorobenzene (DCB) (100 mL) and iodine (catalytic amount) were added, and the reaction mixture was heated to 180±2°C and kept reacting overnight. At the end of the reaction, the solvent was removed under reduced pressure and the product was purified by recrystallization (ethyl acetate: hexane = 90:10) to afford the target compound 5-methylisoquinolin-1(2H)-one (4 g, 45% yield). | | References | [1] Patent: US2013/178457, 2013, A1. Location in patent: Paragraph 0175
[2] Patent: WO2013/5168, 2013, A2. Location in patent: Page/Page column 33
[3] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 8, p. 1147 - 1156
[4] Journal of Heterocyclic Chemistry, 2001, vol. 38, # 4, p. 961 - 964 |
| | 5-METHYL-2H-ISOQUINOLIN-1-ONE Preparation Products And Raw materials |
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