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| | MIPS-21335 Basic information |
| Product Name: | MIPS-21335 | | Synonyms: | MIPS-21335;3-Pyridinecarboxamide, 6-amino-N-[2,3-dihydro-7-methoxy-8-[(3-nitrophenyl)methoxy]imidazo[1,2-c]quinazolin-5-yl]- | | CAS: | 2569296-51-9 | | MF: | C24H21N7O5 | | MW: | 487.47 | | EINECS: | | | Product Categories: | | | Mol File: | 2569296-51-9.mol |  |
| | MIPS-21335 Chemical Properties |
| density | 1.538±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | form | Solid | | pka | 9.982±0.20(predicted) | | color | Off-white to light yellow |
| | MIPS-21335 Usage And Synthesis |
| Uses | MIPS-21335 is an PI3KC2α inhibitor (IC50: 7 nM). MIPS-21335 also inhibits PI3KC2β, p110α, p110β and p110δ (IC50: 0.043, 0.140, 0.386, 0.742 μM). MIPS-21335 has antithrombotic effect[1]. | | References | [1] Selvadurai MV, et al. Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation. Sci Transl Med. 2020 Jul 22;12(553):eaar8430. DOI:10.1126/scitranslmed.aar8430 |
| | MIPS-21335 Preparation Products And Raw materials |
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