|
|
| | 3-Bromo-4-hydroxyphenylacetic acid Basic information |
| | 3-Bromo-4-hydroxyphenylacetic acid Chemical Properties |
| Melting point | 105-107℃ | | Boiling point | 364℃ | | density | 1.757 | | Fp | 174℃ | | storage temp. | Sealed in dry,Room Temperature | | pka | 4.33±0.10(Predicted) | | CAS DataBase Reference | 38692-80-7(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 22 | | HazardClass | IRRITANT |
| | 3-Bromo-4-hydroxyphenylacetic acid Usage And Synthesis |
| Synthesis | Step (b) 3-bromo-4-methoxyphenylacetic acid (14.0 g, 0.057 mol) and anhydrous dichloromethane (100 mL) were added to a 250 mL round bottom flask. The reaction mixture was degassed by nitrogen bubbling for 5 min. Subsequently, a dichloromethane solution of 1 M boron tribromide (63 mL, 0.063 mol) was added slowly and dropwise through the addition funnel. The reaction mixture was stirred at room temperature and a white solid was observed to precipitate gradually. After the reaction was carried out for 2 h, the product was separated by filtration and the collected white crystals were washed several times with dichloromethane to finally obtain 3-bromo-4-hydroxyphenylacetic acid (12 g, 92% yield). | | References | [1] Patent: US2003/114457, 2003, A1
[2] Patent: WO2004/62661, 2004, A1. Location in patent: Page/Page column 28
[3] Patent: US2009/197959, 2009, A1. Location in patent: Page/Page column 14; 15 |
| | 3-Bromo-4-hydroxyphenylacetic acid Preparation Products And Raw materials |
|