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| | (2-Oxopyrrolidin-1-yl)acetic acid Basic information |
| Product Name: | (2-Oxopyrrolidin-1-yl)acetic acid | | Synonyms: | Piracetam Impuirty D;Piracetam EP Impurity D;2-(2-oxopyrrolidin-1-yl)acetate;(2-oxopyrrolidin-1-yl)acetic acid(SALTDATA: FREE);Piracetam Impurity 1;Piracetam Impurity 4(Piracetam EP Impurity D);2-Pyrrolidinon-1-ylacetic acid;2-(2-ketopyrrolidin-1-yl)acetic acid | | CAS: | 53934-76-2 | | MF: | C6H9NO3 | | MW: | 143.14 | | EINECS: | | | Product Categories: | | | Mol File: | 53934-76-2.mol |  |
| | (2-Oxopyrrolidin-1-yl)acetic acid Chemical Properties |
| Melting point | 143℃ (benzene ) | | Boiling point | 379.1±25.0 °C(Predicted) | | density | 1.319±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly) | | pka | 3.75±0.10(Predicted) | | form | Solid | | Appearance | Off-white to light yellow Solid |
| | (2-Oxopyrrolidin-1-yl)acetic acid Usage And Synthesis |
| Uses | (2-Oxopyrrolidin-1-yl)acetic acid is a reagent in the preparation of pyrazolopyridines as PDE4B inhibitors. | | Synthesis | Benzyl (2-oxopyrrolidin-1-yl) acetate (233 mg, 1.0 mmol) was dissolved in methanol (5 mL) at 23 °C and 10 wt% Pd/C catalyst (100 mg) was added. The reaction mixture was deoxygenated using a vacuum pump and subsequently reacted under hydrogen atmosphere (using a hydrogen balloon).After 3 h, the reaction mixture was filtered through a diatomaceous earth pad and the diatomaceous earth pad was washed with methanol (100 mL). The combined filtrates were concentrated under reduced pressure to afford (2-oxopyrrolidin-1-yl)acetic acid (143 mg, 100% yield). | | References | [1] Patent: US2006/211603, 2006, A1. Location in patent: Page/Page column 76 |
| | (2-Oxopyrrolidin-1-yl)acetic acid Preparation Products And Raw materials |
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