N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE manufacturers
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| | N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE Basic information |
| Product Name: | N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE | | Synonyms: | N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE;4-(2-Bromoethyl)-1-(tert-butoxycarbonyl)piperidine;4-(2-Bromoethyl)piperidine-1-carboxylic acid tert-butyl ester;1-Boc-4-(2-bromoethyl)piperidine;1-Piperidinecarboxylic acid, 4-(2-bromoethyl)-, 1,1-dimethylethyl ester;4-(2-bromoethyl)piperidine-1-carboxylate | | CAS: | 169457-73-2 | | MF: | C12H22BrNO2 | | MW: | 292.21 | | EINECS: | | | Product Categories: | | | Mol File: | 169457-73-2.mol |  |
| | N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE Chemical Properties |
| Melting point | 39-42℃ | | Boiling point | 334.2±15.0 °C(Predicted) | | density | 1.241±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | -1.52±0.40(Predicted) | | form | liquid | | color | Colourless | | InChI | InChI=1S/C12H22BrNO2/c1-12(2,3)16-11(15)14-8-5-10(4-7-13)6-9-14/h10H,4-9H2,1-3H3 | | InChIKey | CLBWAEYOPRGKBT-UHFFFAOYSA-N | | SMILES | N1(C(OC(C)(C)C)=O)CCC(CCBr)CC1 |
| | N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of N-Boc-4-(2-bromoethyl)piperidine from N-Boc-4-piperidine ethanol: N-Boc-4-(2-hydroxyethyl)piperidine (0.95 g, 4.17 mmol) was dissolved in anhydrous tetrahydrofuran (20 mL), followed by carbon tetrabromide (1.34 g, 4.0 mmol). A solution of triphenylphosphine (1.15 g, 4.38 mmol) in anhydrous tetrahydrofuran (2 mL) was added slowly and dropwise over 2 hours. The reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, ether (50 mL) was added to the mixture, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent ratio 9:1 hexane:ethyl acetate) to afford the target product N-Boc-4-(2-bromoethyl)piperidine (1.05 g, 86% yield) as an oil. | | References | [1] RSC Advances, 2016, vol. 6, # 52, p. 46170 - 46185
[2] Patent: US2007/32469, 2007, A1. Location in patent: Page/Page column 46
[3] Patent: US2009/192169, 2009, A1. Location in patent: Page/Page column 60
[4] Patent: US2013/184313, 2013, A1. Location in patent: Paragraph 1666
[5] Patent: WO2008/27521, 2008, A1. Location in patent: Page/Page column 63 |
| | N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE Preparation Products And Raw materials |
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