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| | JKC-301 Basic information |
| Product Name: | JKC-301 | | Synonyms: | CYCLO(-D-ASP-PRO-D-ILE-LEU-D-TRP);JKC 301 (CYCLO-[D-ASP-PRO-D-LLE-LEU-D-TR P]), SYNTHETIC, >99% PURITY;JKC-301;Cyclo(D-α-aspartyl-L-prolyl-D-isoleucyl-L-leucyl-D-tryptophyl);JKC-301 Cyclo(-D-Asp-Pro-D-Ile-Leu-D-Trp) | | CAS: | 136553-96-3 | | MF: | C32H44N6O7 | | MW: | 624.73 | | EINECS: | | | Product Categories: | | | Mol File: | 136553-96-3.mol |  |
| | JKC-301 Chemical Properties |
| Boiling point | 1052.2±65.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | -15°C | | pka | 4.04±0.10(Predicted) | | Sequence | Cyclo({d-Asp}-Pro-{d-Ile}-Leu-{d-Trp}) |
| | JKC-301 Usage And Synthesis |
| Uses | JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking[1][2]. | | References | [1] Tanus-Santos JE, Sampaio RC, Hyslop S, Franchini KG, Moreno H Jr. Endothelin ET(A) receptor antagonism attenuates the pressor effects of nicotine in rats. Eur J Pharmacol. 2000 May 12;396(1):33-7. DOI:10.1016/s0014-2999(00)00194-1
[2] Ngoka LC, et al. Location of alkali metal binding sites in endothelin A selective receptor antagonists, cyclo(D-Trp-D-Asp-Pro-D-Val-Leu) and cyclo(D-Trp-D-Asp-Pro-D-Ile-Leu), from multistep collisionally activated decompositions. J Mass Spectrom. 2000 Feb;35(2):265-76. DOI:10.1002/(SICI)1096-9888(200002)35:2<265::AID-JMS946>3.0.CO;2-# |
| | JKC-301 Preparation Products And Raw materials |
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