8-ISO prostaglandin F2BeTa manufacturers
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| | 8-ISO prostaglandin F2BeTa Basic information |
| Product Name: | 8-ISO prostaglandin F2BeTa | | Synonyms: | 8-ISO-9BETA-PGF2ALPHA;9BETA,11ALPHA,15S-TRIHYDROXY-(8BETA)-PROSTA-5Z,13E-DIEN-1-OIC ACID;9alpha,11alpha,15S-trihydroxy-(8beta)-prost-5Z,13E-dien-1-oic-acid;(Z)-7-[(1S,2R,3R,5R)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid;8-isoprostaglandin PGF2beta;PXGPLTODNUVGFL-HMALSPAFSA-N;8-iso Prostaglandin F2β;Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,8β,9β,11α,13E,15S)- | | CAS: | 177020-26-7 | | MF: | C20H34O5 | | MW: | 354.48 | | EINECS: | | | Product Categories: | | | Mol File: | 177020-26-7.mol |  |
| | 8-ISO prostaglandin F2BeTa Chemical Properties |
| Boiling point | 531.0±50.0 °C(Predicted) | | density | 1.153±0.06 g/cm3(Predicted) | | solubility | 10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a) | | pka | 4.76±0.10(Predicted) |
| | 8-ISO prostaglandin F2BeTa Usage And Synthesis |
| Description | 8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α with a non-enzymatic, non-cyclooxygenase origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE1, 8-iso PGE2, or 8-iso PGF2α | | Uses | 8-iso Prostaglandin F2β (8-iso PGF2β) is a biomarker for assessing oxidative stress, and its content in serum can indirectly reflect the level of oxidative stress[1]. | | References | [1] Shaker S R, Al-Amran F, Fatima G, et al. Trimetazidine improves the outcome of EECP therapy in patients with refractory angina pectoris[J]. Medical Archives, 2020, 74(3): 199. |
| | 8-ISO prostaglandin F2BeTa Preparation Products And Raw materials |
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