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| | TEBUPIRIMFOS Basic information |
| | TEBUPIRIMFOS Chemical Properties |
| Boiling point | 359℃ | | density | 1.146 | | vapor pressure | 5mPa(20℃) | | Fp | 171℃ | | storage temp. | 2-8°C | | pka | 0.46±0.22(Predicted) | | Water Solubility | 5.5mg/L(20℃, pH7) | | Henry's Law Constant | 3.5×100 mol/(m3Pa) at 25℃, HSDB (2015) | | InChI | 1S/C13H23N2O3PS/c1-7-16-19(20,17-10(2)3)18-11-8-14-12(15-9-11)13(4,5)6/h8-10H,7H2,1-6H3 | | InChIKey | AWYOMXWDGWUJHS-UHFFFAOYSA-N | | SMILES | CCOP(=S)(OC(C)C)Oc1cnc(nc1)C(C)(C)C | | EPA Substance Registry System | Phostebupirim (96182-53-5) |
| Hazard Codes | T+,N | | Risk Statements | 26/27/28-50/53 | | Safety Statements | 28-36/37-45-60-61 | | RIDADR | UN 2810 6.1/PG 1 | | WGK Germany | 3 | | RTECS | TF8750000 | | HazardClass | 6.1 | | PackingGroup | I | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Oral
Aquatic Acute 1 | | Hazardous Substances Data | 96182-53-5(Hazardous Substances Data) |
| | TEBUPIRIMFOS Usage And Synthesis |
| Chemical Properties | Phostebupirim is an amber-to-brown liquid. Phostebuprim
hydrolyzes under alkaline conditions.Soluble in water at 5.5 mg/mL; completely
miscible with all solvents tested at 20°C. | | Uses | Tebupirimfos is an organophosphorous insecticide developped for soil application. | | Definition | ChEBI: Tebupirimfos is an organic thiophosphate and an organothiophosphate insecticide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is functionally related to a 2-tert-butylpyrimidin-5-ol. | | Mechanism of action | Contact action with residual effects. Acetylcholinesterase (AchE) inhibitor. | | Synthesis | The industrial synthesis of butylpyrimidine phosphorus is carried out by a one-pot method: first, 2-tert-butyl-5-hydroxypyrimidine reacts with trichlorophosphorus (PSCl₃) under alkaline catalysis to generate a thiophosphate chloride intermediate, and then the intermediate undergoes a two-step esterification reaction with ethanol and isopropanol to obtain Tebupirimfos. | | Toxicity evaluation | The acute oral LD50 for rats
is 1.3–3.6 mg/kg. Inhalation LC50 (4 h) for rats is
36–82 mg/m3 air. NOEL (2 yr) for rats is 1 mg/kg diet(0.05 mg/kg/d). ADI is 0.2 μg/kg b.w. | | Pesticide Type | Insecticide |
| | TEBUPIRIMFOS Preparation Products And Raw materials |
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