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| | ANANTIN (LINEAR SEQUENCE) Basic information |
| Product Name: | ANANTIN (LINEAR SEQUENCE) | | Synonyms: | anantin from streptomyces coerulescens;CYCLO[GLY-PHE-ILE-GLY-TRP-GLY-ASN-BETA-ASP]-ILE-PHE-GLY-HIS-TYR-SER-GLY-ASP-PHE;GLY-PHE-ILE-GLY-TRP-GLY-ASN-ASP-ILE-PHE-GLY-HIS-TYR-SER-GLY-ASP-PHE;H-GLY-PHE-ILE-GLY-TRP-GLY-ASN-ASP-ILE-PHE-GLY-HIS-TYR-SER-GLY-ASP-PHE-OH;ANANTIN;ANANTIN (LINEAR SEQUENCE);Cyclo[L-Phe-L-Ile-Gly-L-Trp-Gly-L-Asn-L-βαAsp-(L-Ile-L-Phe-Gly-L-His-L-Tyr-L-Ser-Gly-L-Asp-L-Phe-OH)-Gly-];Cyclo[L-Phe-L-Ile-Gly-L-Trp-Gly-L-Asn-βαAsp-(L-Ile-L-Phe-Gly-L-His-L-Tyr-L-Ser-Gly-L-Asp-L-Phe-OH)-Gly-] | | CAS: | 133658-45-4 | | MF: | C90H111N21O24 | | MW: | 1870.97 | | EINECS: | | | Product Categories: | | | Mol File: | 133658-45-4.mol |  |
| | ANANTIN (LINEAR SEQUENCE) Chemical Properties |
| storage temp. | −20°C | | Sequence | Gly-Phe-Ile-Gly-Trp-Gly-Asn-Asp-Ile-Phe-Gly-His-Tyr-Ser-Gly-Asp-Phe (Lactam bridge:Gly1-Asp8) |
| | ANANTIN (LINEAR SEQUENCE) Usage And Synthesis |
| Uses | Anantin binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine adrenal cortex (Kd = 0.6 μM) and acts as natriuretic peptide receptor A antagonist[1][2]. | | References | [1] Wyss DF,et al. Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of proton assignments. J Antibiot (Tokyo). 1991 Feb;44(2):172-80.https://pubmed.ncbi.nlm.nih.gov/1826288/1. Wyss DF,et al. Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of proton assignments. J Antibiot (Tokyo). 1991 Feb;44(2):172-80. DOI:10.7164/antibiotics.44.172
[2] Nachshon S, et al. Effects of ANP receptor antagonists on ANP secretion from adult rat cultured atrial myocytes. Am J Physiol. 1995 Mar;268(3 Pt 1):E428-32. DOI:10.1152/ajpendo.1995.268.3.E428 |
| | ANANTIN (LINEAR SEQUENCE) Preparation Products And Raw materials |
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