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Sigma-Aldrich |
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
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| | L-Glutamic acid (1-13C) Basic information |
| | L-Glutamic acid (1-13C) Chemical Properties |
| Melting point | 205 °C (dec.)(lit.) | | density | 1.410±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | form | Solid | | color | White to off-white | | Optical Rotation | [α]25/D +31°, c =2 in 5 M HCl | | CAS Number Unlabeled | 56-86-0 |
| | L-Glutamic acid (1-13C) Usage And Synthesis |
| Uses | L-Glutamic acid-1-13C is the 13C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals. | | IC 50 | NMDA Receptor | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6(1):73-7. DOI:10.1016/0304-3940(77)90068-4 |
| | L-Glutamic acid (1-13C) Preparation Products And Raw materials |
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