|
|
| | 1-(2-Chlorophenyl)piperazine hydrochloride Basic information |
| | 1-(2-Chlorophenyl)piperazine hydrochloride Chemical Properties |
| Melting point | 160-163 °C (dec.)(lit.) | | storage temp. | Store at room temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White | | Sensitive | Hygroscopic | | BRN | 5652889 | | CAS DataBase Reference | 41202-32-8(CAS DataBase Reference) |
| | 1-(2-Chlorophenyl)piperazine hydrochloride Usage And Synthesis |
| Uses | 1-(2-Chlorophenyl)piperazine Hydrochloride is a reactant used in the preparation of piperazinyl, phenylpiperidinyl, tetrahydropyridinyl, and tetrahydropyridoindolylbutylbenzindoles with 5-hydroxytryptamine receptor antagonist activity. | | Synthesis | To a stirred solution of tert-butyl 4-(2-chlorophenyl)piperazine-1-carboxylate (250 mg, 0.844 mmol) in 1,4-dioxane (2 mL) was added slowly and dropwise a 1,4-dioxane solution (0.9 mL, 3.60 mmol) in 4 N HCl at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 h (complete consumption of feedstock was confirmed by TLC monitoring). Upon completion of the reaction, the volatile solvent was removed under reduced pressure to give the crude product. The crude product was washed with ether (2 x 20 mL) and dried under high vacuum to yield 1-(2-chlorophenyl)piperazine hydrochloride (165 mg, 84% yield) as a white solid. | | References | [1] Patent: WO2018/125961, 2018, A1. Location in patent: Page/Page column 45; 46 |
| | 1-(2-Chlorophenyl)piperazine hydrochloride Preparation Products And Raw materials |
|