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BOC Sciences
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| Products Intro: |
Product Name:Brevetoxin PbTx-3
CAS:85079-48-7
Purity:95 % (HPLC). Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
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marketing@tsbiochem.com |
| Products Intro: |
Product Name:Brevetoxin-3
CAS:85079-48-7
Package:100μg/RMB 8900
|
BREVETOXIN PBTX-3 manufacturers
- Brevetoxin-3
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- $1270.00 / 100μg
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2026-01-05
- CAS:85079-48-7
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | BREVETOXIN PBTX-3 Basic information |
| Product Name: | BREVETOXIN PBTX-3 | | Synonyms: | DIHYDROBREVETOXIN B;BREVETOXIN PBTX-3;BREVETOXIN PBTX-3, PTYCHODISCUS BREVIS;PUMILIOTOXIN;brevetoxint17;toxint-17;Brevetoxin B, 42-deoxo-42-hydroxy-;PBTX-3 | | CAS: | 85079-48-7 | | MF: | C50H72O14 | | MW: | 897.1 | | EINECS: | | | Product Categories: | | | Mol File: | 85079-48-7.mol |  |
| | BREVETOXIN PBTX-3 Chemical Properties |
| density | 1.190±0.06 g/cm3(Predicted) | | storage temp. | -20C | | solubility | DMSO: soluble,Ethanol: soluble,Methanol: soluble | | form | Solid | | pka | 13.78±0.70(Predicted) | | color | White to off-white | | InChIKey | BKMHDYJRAAJTAD-FGRVLNGBSA-N |
| RIDADR | 3172 | | WGK Germany | WGK 2 | | RTECS | XW5885000 | | HazardClass | 6.1(a) | | PackingGroup | I | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2 |
| | BREVETOXIN PBTX-3 Usage And Synthesis |
| Uses | Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain)[1]. Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na+channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation[2]. | | General Description | Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites. | | Biochem/physiol Actions | Primary TargetVoltage-dependent Na+ channel activator | | Safety Profile | A poison by ingestion,
intraperitoneal, and intravenous routes.
When heated to decomposition it emits
acrid smoke and irritating vapors. | | in vivo | Brevetoxin-3 (PbTx-3)(intratracheal instillation; 2.8 μg/kg; gestational days 15-18)radioactivity is detected in placentas and fetuses within 0.5 hours. Concentrations of brevetoxin equivalents in fetuses are approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh. Following brevetoxin infusion, concentration of brevetoxin equivalents in fetuses is 0.1 ng/g, lower than that present in most maternal tissues[3].
. | Animal Model: | Pregnant CD-1 mice[3] | | Dosage: | 2.8 μg/kg | | Administration: | Intratracheal instillation; 2.8 μg/kg; gestational days 15–18 | | Result: | Demonstrated placental transport of brevetoxin or its metabolites following maternal acute exposure. |
| | References | [1] Jeglitsch G,et al. Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons.J Pharmacol Exp Ther. 1998 Feb;284(2):516-25. PMID:9454792
[2] Zaias J,et al. Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep.Inhal Toxicol. 2011 Mar;23(4):205-11. DOI:10.3109/08958378.2011.558936
[3] Benson JM, et al. Placental transport of brevetoxin-3 in CD-1 mice.Toxicon.2006 Dec 15;48(8):1018-26. Epub 2006 Aug 18. DOI:10.1016/j.toxicon.2006.08.008 |
| | BREVETOXIN PBTX-3 Preparation Products And Raw materials |
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