| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
| Company Name: |
Energy Chemical |
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400-0056266 |
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1,10-Phenanthrolinium chloride monohydrate manufacturers
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| | 1,10-Phenanthrolinium chloride monohydrate Basic information |
| | 1,10-Phenanthrolinium chloride monohydrate Chemical Properties |
| Melting point | 224-225 °C(lit.) | | bulk density | 370kg/m3 | | storage temp. | Inert atmosphere,Room Temperature | | solubility | H2O: 0.1 g/mL, clear | | form | Solid | | color | Colorless crystals | | Water Solubility | Soluble in water. | | BRN | 4007967 | | Stability: | Stable for 2 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. | | InChI | 1S/C12H8N2.ClH.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;/h1-8H;1H;1H2 | | InChIKey | NDLHUHRGAIHALB-UHFFFAOYSA-N | | SMILES | O.Cl.c1cnc2c(c1)ccc3cccnc23 |
| Hazard Codes | T,N | | Risk Statements | 25-50/53 | | Safety Statements | 45-60-61 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | F | 8 | | TSCA | Yes | | HS Code | 2933 99 80 | | HazardClass | 6.1 | | PackingGroup | III | | Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 1 | | Toxicity | LD50 orally in Rabbit: 132 mg/kg |
| | 1,10-Phenanthrolinium chloride monohydrate Usage And Synthesis |
| Description | 1,10-Phenanthroline (18851-33-7) is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1 It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an active site Zn2+. It may be used when preparing cell lysates for enrichment of ubiquitinated proteins which are especially sensitive to DUBs in the JAMM family.2,3 | | Chemical Properties | White fine crystalline powder | | Uses | 1,10-Phenanthroline monohydrochloride monohydrate is used as an analytical reagent for colorimetric determination of iron. | | References | [1] J C SWANN W A G J J Reynolds. Zinc metalloenzyme properties of active and latent collagenase from rabbit bone.[J]. Biochemical Journal, 1981, 195 1: 41-49. DOI:10.1042/bj1950041 [2] ERIC M COOPER. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1.[J]. EMBO Journal, 2009, 28 6: 621-631. DOI:10.1038/emboj.2009.27 [3] YING LU. Substrate degradation by the proteasome: A single-molecule kinetic analysis[J]. Science, 2015, 348 6231. DOI:10.1126/science.1250834 |
| | 1,10-Phenanthrolinium chloride monohydrate Preparation Products And Raw materials |
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