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1,10-Phenanthrolinium chloride monohydrate

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1,10-Phenanthrolinium chloride monohydrate Basic information
Product Name:1,10-Phenanthrolinium chloride monohydrate
Synonyms:1,10-PHENANTHROLINE HYDROCHLORIDE;1,10-PHENANTHROLINE CHLORIDE MONOHYDRATE;1,10-PHENANTHROLINE HYDROCHLORIDE MONOHYDRATE;1,10-PHENANTHROLINE HYDROCHLORIDE MONOHYDRATE (O-);1,10-Phenanthroline monohydrochloride monohydrate 97%;1,10-Phenanthroline hydrochloride hydrate (1:1:1);O-PHENANTHROLINE HYDROCHLORIDE MONOHYDRATE;1,10-PhenanthrolineHydrochlorideGr
CAS:18851-33-7
MF:C12H11ClN2O
MW:234.68
EINECS:627-064-8
Product Categories:Amine Salts;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Antibiotics;Antibiotics A to Z;Antibiotics N-S;Heterocyclic Building Blocks;N-Containing;Others
Mol File:18851-33-7.mol
1,10-Phenanthrolinium chloride monohydrate Structure
1,10-Phenanthrolinium chloride monohydrate Chemical Properties
Melting point 224-225 °C(lit.)
bulk density370kg/m3
storage temp. Inert atmosphere,Room Temperature
solubility H2O: 0.1 g/mL, clear
form Solid
color Colorless crystals
Water Solubility Soluble in water.
BRN 4007967
Stability:Stable for 2 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
InChI1S/C12H8N2.ClH.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;/h1-8H;1H;1H2
InChIKeyNDLHUHRGAIHALB-UHFFFAOYSA-N
SMILESO.Cl.c1cnc2c(c1)ccc3cccnc23
Safety Information
Hazard Codes T,N
Risk Statements 25-50/53
Safety Statements 45-60-61
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
8
TSCA Yes
HS Code 2933 99 80
HazardClass 6.1
PackingGroup III
Storage Class6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard ClassificationsAcute Tox. 3 Oral
Aquatic Acute 1
Aquatic Chronic 1
ToxicityLD50 orally in Rabbit: 132 mg/kg
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
1,10-Phenanthrolinium chloride monohydrate Usage And Synthesis
Description1,10-Phenanthroline (18851-33-7) is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1 It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an active site Zn2+. It may be used when preparing cell lysates for enrichment of ubiquitinated proteins which are especially sensitive to DUBs in the JAMM family.2,3
Chemical PropertiesWhite fine crystalline powder
Uses1,10-Phenanthroline monohydrochloride monohydrate is used as an analytical reagent for colorimetric determination of iron.
References[1] J C SWANN  W A G  J J Reynolds. Zinc metalloenzyme properties of active and latent collagenase from rabbit bone.[J]. Biochemical Journal, 1981, 195 1: 41-49. DOI:10.1042/bj1950041
[2] ERIC M COOPER. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1.[J]. EMBO Journal, 2009, 28 6: 621-631. DOI:10.1038/emboj.2009.27
[3] YING LU. Substrate degradation by the proteasome: A single-molecule kinetic analysis[J]. Science, 2015, 348 6231. DOI:10.1126/science.1250834
1,10-Phenanthrolinium chloride monohydrate Preparation Products And Raw materials
Tag:1,10-Phenanthrolinium chloride monohydrate(18851-33-7) Related Product Information
ZPCK o-Phenanthroline Neocuproine hydrochloride hydrate 98 1,10-Phenanthroline iron(II) perchlorate Neocuproine hydrochloride 1,10-Phenanthrolinium chloride monohydrate 1,10-PHENANTHROLINE HYDROCHLORIDE PHENANTHROLINE RUTHENIUM DICHLORIDE, HYDRATE Tris(4 7-diphenyl-1 10-phenanthroline)ru (1,10-Phenanthroline)bis(triphenylphosphine)copper (I) nitrate dichloromethane adduct Dichlorotris(1,10-phenanthroline)ruthenium(II) hydrate Neocuproine hydrochloride 4,7-Dihydroxy-1,10-phenanthroline hydrochloride 5-Methyl-1,10-phenanthroline ferrous perchlorate 5-Nitro-1,10-phenanthroline ferrous perchlorate 1,10-Phenanthrolinium chloride monohydrate p.a. delta-(-)-D-Tris(1,10-phenan- throline)ruthenium(II) diperchlorate 2,9-Dimethyl-1,10-phenanthroline hydrochloride monohydrate